Detailed information of TA system TA233802

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 69389..69642
• Replicon: plasmid p143-3
• Accession: NZ_CP091565
• Organism: Salmonella enterica strain 143

Toxin (Protein)

• Gene name: srnB
• Uniprot ID: G9G1E3
• Locus tag: INN77_RS26790
• Protein ID: WP_001312851.1
• Coordinates: 69493..69642 (+)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	69389..69448 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN77_RS26755 (65165)	65165..66025	+	861	WP_000704524.1	alpha/beta hydrolase	-
INN77_RS26760 (66128)	66128..66688	+	561	WP_000139321.1	fertility inhibition protein FinO	-
INN77_RS26765 (66817)	66817..67029	+	213	WP_001309245.1	ANR family transcriptional regulator	-
INN77_RS26770 (67274)	67274..67735	+	462	WP_001233842.1	thermonuclease family protein	-
INN77_RS26775 (67781)	67781..67990	+	210	WP_001298565.1	hemolysin expression modulator Hha	-
INN77_RS26780 (68028)	68028..68618	+	591	WP_000766807.1	DUF2726 domain-containing protein	-
INN77_RS26785 (68773)	68773..69246	+	474	WP_016240489.1	hypothetical protein	-
- (69389)	69389..69448	-	60	NuclAT_1	-	Antitoxin
- (69389)	69389..69448	-	60	NuclAT_1	-	Antitoxin
- (69389)	69389..69448	-	60	NuclAT_1	-	Antitoxin
- (69389)	69389..69448	-	60	NuclAT_1	-	Antitoxin
INN77_RS26790 (69493)	69493..69642	+	150	WP_001312851.1	Hok/Gef family protein	Toxin
INN77_RS26795 (69927)	69927..70175	+	249	WP_000083839.1	replication regulatory protein RepA	-
INN77_RS26800 (70290)	70290..70474	+	185	Protein_92	protein CopA/IncA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..70486	70486

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (4-45)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5542.67 Da
• Isoelectric Point: 8.7678

>T233802 WP_001312851.1 NZ_CP091565:69493-69642 [Salmonella enterica]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Nucleotide

• Length: 150 bp

>T233802 NZ_LN824134:c13146-12676 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTTTTTTACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCTCTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAACTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATTGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Nucleotide

• Length: 60 bp

>AT233802 NZ_CP091565:c69448-69389 [Salmonella enterica]
AATGTACTTCATGCAGACCTCACGAGTTAATGGATTAACAAGTGGGGTCTTTGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A829C8K5

Antitoxin