Detailed information of TA system TA233799

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 28001..28270
• Replicon: plasmid p143-3
• Accession: NZ_CP091565
• Organism: Salmonella enterica strain 143

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: INN77_RS26540
• Protein ID: WP_001372321.1
• Coordinates: 28145..28270 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	28001..28066 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN77_RS26505	23007..23468	-	462	Protein_33	hypothetical protein	-
INN77_RS26510	23770..24297	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
INN77_RS26515	24355..24588	+	234	WP_000006003.1	DUF905 family protein	-
INN77_RS26520	24649..26613	+	1965	WP_025746229.1	ParB/RepB/Spo0J family partition protein	-
INN77_RS26525	26682..27116	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
INN77_RS26530	27113..27832	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
-	27844..28068	+	225	NuclAT_0	-	-
-	27844..28068	+	225	NuclAT_0	-	-
-	27844..28068	+	225	NuclAT_0	-	-
-	27844..28068	+	225	NuclAT_0	-	-
-	28001..28066	-	66	-	-	Antitoxin
INN77_RS26535	28054..28203	+	150	Protein_39	plasmid maintenance protein Mok	-
INN77_RS26540	28145..28270	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
INN77_RS26545	28571..28867	-	297	Protein_41	hypothetical protein	-
INN77_RS26550	29167..29463	+	297	WP_001272251.1	hypothetical protein	-
INN77_RS26555	29574..30395	+	822	WP_001234445.1	DUF932 domain-containing protein	-
INN77_RS26560	30692..31294	-	603	WP_000243713.1	transglycosylase SLT domain-containing protein	-
INN77_RS26565	31615..31998	+	384	WP_001151529.1	conjugal transfer relaxosome DNA-binding protein TraM	-
INN77_RS26570	32190..32837	+	648	WP_000332523.1	transcriptional regulator TraJ family protein	-
INN77_RS26575	32957..33184	+	228	WP_000589556.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..70486	70486

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T233799 WP_001372321.1 NZ_CP091565:28145-28270 [Salmonella enterica]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T233799 NZ_LN824133:c4523015-4522605 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT233799 NZ_CP091565:c28066-28001 [Salmonella enterica]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Structures

Antitoxin