Detailed information of TA system TA233798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelE-RHH
• Location: 1773..2320
• Replicon: plasmid p143-3
• Accession: NZ_CP091565
• Organism: Salmonella enterica strain 143

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: INN77_RS26350
• Protein ID: WP_244493824.1
• Coordinates: 2042..2320 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A6G9U792
• Locus tag: INN77_RS26345
• Protein ID: WP_000079935.1
• Coordinates: 1773..2042 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
INN77_RS26340 (1)	1..858	+	858	WP_016240488.1	incFII family plasmid replication initiator RepA	-
INN77_RS26345 (1773)	1773..2042	+	270	WP_000079935.1	type II toxin-antitoxin system antitoxin YacA	Antitoxin
INN77_RS26350 (2042)	2042..2320	+	279	WP_244493824.1	type II toxin-antitoxin system toxin YacB	Toxin
INN77_RS26355 (2366)	2366..3214	+	849	WP_115198154.1	3'-5' exonuclease	-
INN77_RS26360 (3331)	3331..3813	+	483	WP_001311056.1	hypothetical protein	-
INN77_RS26365 (4173)	4173..5289	-	1117	Protein_5	IS91 family transposase	-
INN77_RS26370 (5289)	5289..5654	-	366	WP_000124093.1	hypothetical protein	-
INN77_RS26375 (6182)	6182..6691	+	510	WP_000115002.1	peptide deformylase	-
INN77_RS26380 (6706)	6706..6807	+	102	Protein_8	methionyl-tRNA formyltransferase	-
INN77_RS26385 (7004)	7004..7195	+	192	WP_000175572.1	DUF2164 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..70486	70486
	-	flank	IS/Tn	-	-	4204..4926	722

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10729.37 Da
• Isoelectric Point: 8.4615

>T233798 WP_244493824.1 NZ_CP091565:2042-2320 [Salmonella enterica]
MEIFWTMLASQDRKRIREYIAEQNLIAAIELDERIGYSASSLAGLPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKVY
ILRVLHTAQKWP

Nucleotide

• Length: 279 bp

>T233798 NZ_LN824133:c3863051-3862635 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATTATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACCGACATCCGGGTGGCGCTGCACCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCTGGACTGACACTGG
AAGACTGGGTTATTTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10198.53 Da
• Isoelectric Point: 8.8735

>AT233798 WP_000079935.1 NZ_CP091565:1773-2042 [Salmonella enterica]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVAAGRQQLERGDVLTHDMVESSAAAWRD
EMSRKVAGK

Nucleotide

• Length: 270 bp

>AT233798 NZ_LN824133:c3863278-3863048 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Structures

Antitoxin

• AlphaFold DB: A0A6G9U792