Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 207307..208067 Replicon chromosome
Accession NZ_CP091544
Organism Salmonella enterica strain 1618

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag L4414_RS00975 Protein ID WP_000533909.1
Coordinates 207582..208067 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag L4414_RS00970 Protein ID WP_000965886.1
Coordinates 207307..207594 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L4414_RS00945 (202602) 202602..202904 + 303 WP_000605590.1 YsaB family lipoprotein -
L4414_RS00950 (203043) 203043..203954 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
L4414_RS00955 (203964) 203964..206033 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
L4414_RS00960 (206215) 206215..206490 + 276 Protein_191 IS3 family transposase -
L4414_RS00965 (206662) 206662..207129 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
L4414_RS00970 (207307) 207307..207594 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
L4414_RS00975 (207582) 207582..208067 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
L4414_RS00980 (208439) 208439..208978 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
L4414_RS00985 (209152) 209152..209364 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
L4414_RS00990 (209653) 209653..209943 - 291 WP_000455790.1 HTH-type transcriptional regulator -
L4414_RS00995 (210382) 210382..211092 + 711 WP_000190524.1 DUF3053 domain-containing protein -
L4414_RS01000 (211142) 211142..212116 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
L4414_RS01005 (212335) 212335..212997 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T233623 WP_000533909.1 NZ_CP091544:207582-208067 [Salmonella enterica]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T233623 NZ_HG999363:65940-66209 [Xanthomonas euroxanthea]
GTGGCCGACCTGGACGCGATTGCCGACTACATTGCACTTGAGGACGCAGCCGCCGCAGCGGCACTGGTGAGACGGGTGGT
TGCGCATGTCGAGCAATTGGCCGAGCACCCGGAGAGCGGGAGCCGCCCGCAGGAGCTCAAGCGCTCCCGCTACCGTCAAA
TCGTCGAACCACCGTGCCGCGTGTTCTACCGTGTGGATGGGCAGCGCGTCGTCGTGGTTCACGTGATGCGCTCGGAGCGG
TTACTCCGGAGAAATCGTCTTTCGCGCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT233623 WP_000965886.1 NZ_CP091544:207307-207594 [Salmonella enterica]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT233623 NZ_HG999363:65665-65922 [Xanthomonas euroxanthea]
ATGCGCACAGAACTTGTCACCACGCTCAAGCGTCAGGCCACCGAACTCCTCGCTGATGTCGAGCGCGACAAGGAGCCGAT
CCTGATTACCCAGCATGGTCTGCCCAGCGCATATCTGGTCGATGTCACCAGCTATGAGCGCCTGCAGCAGCGGATGGCGA
TCCTCGAAGGTATCGCCCGTGGTGAAATGGCGGTAGCGGAAGGCCGCAGCCTGAGCCACGAGCAGGCCAAACAACGCCTG
GCGCGATGGCTGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References