Detailed information of TA system TA233583

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2119033..2119258
• Replicon: chromosome
• Accession: NZ_CP091540
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain S46L1

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: L5Z03_RS10420
• Protein ID: WP_000813254.1
• Coordinates: 2119103..2119258 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2119033..2119091 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5Z03_RS10390	2114471..2115217	+	747	WP_052929112.1	ATP-binding protein	-
L5Z03_RS10395	2115240..2116001	+	762	WP_139707682.1	DUF1627 domain-containing protein	-
L5Z03_RS10400	2116017..2116439	+	423	WP_050306692.1	DUF977 family protein	-
L5Z03_RS10405	2116436..2116636	+	201	WP_042973267.1	hypothetical protein	-
L5Z03_RS10410	2116910..2117488	+	579	WP_001204666.1	sce7726 family protein	-
L5Z03_RS10415	2117448..2118545	-	1098	WP_042973270.1	beta family protein	-
-	2119033..2119091	-	59	-	-	Antitoxin
L5Z03_RS10420	2119103..2119258	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
L5Z03_RS10425	2119534..2119746	+	213	WP_052929182.1	hypothetical protein	-
L5Z03_RS10430	2119818..2120417	+	600	WP_052929183.1	DUF1367 family protein	-
L5Z03_RS10435	2120417..2120707	+	291	WP_001533370.1	DUF1364 domain-containing protein	-
L5Z03_RS10440	2120704..2121246	+	543	WP_000640144.1	DUF1133 family protein	-
L5Z03_RS10445	2121730..2122065	+	336	WP_001533367.1	phage holin, lambda family	-
L5Z03_RS10450	2122069..2122545	+	477	WP_001194114.1	glycoside hydrolase family protein	-
L5Z03_RS10455	2122529..2122921	+	393	WP_042043867.1	DUF2570 domain-containing protein	-
L5Z03_RS10460	2122806..2123084	+	279	WP_173671027.1	hypothetical protein	-
L5Z03_RS10465	2123065..2123250	+	186	WP_000113285.1	hypothetical protein	-
L5Z03_RS10470	2123383..2123931	-	549	WP_000762846.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sopE2	2082764..2165138	82374

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T233583 WP_000813254.1 NZ_CP091540:2119103-2119258 [Salmonella enterica subsp. enterica serovar Typhimurium]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T233583 NZ_HG994850:c3946387-3945989 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT233583 NZ_CP091540:c2119091-2119033 [Salmonella enterica subsp. enterica serovar Typhimurium]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin