Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2626683..2627362 Replicon chromosome
Accession NZ_CP091346
Organism Acinetobacter baumannii strain AB217-VUB

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag L2Z30_RS12940 Protein ID WP_000838146.1
Coordinates 2627180..2627362 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID N9L2H6
Locus tag L2Z30_RS12935 Protein ID WP_000966688.1
Coordinates 2626683..2627087 (-) Length 135 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Z30_RS12895 (L2Z30_12895) 2621722..2622069 - 348 WP_057078074.1 hypothetical protein -
L2Z30_RS12900 (L2Z30_12900) 2622193..2622702 - 510 WP_057078075.1 Rha family transcriptional regulator -
L2Z30_RS12905 (L2Z30_12905) 2622838..2623767 - 930 WP_057078076.1 ORF6N domain-containing protein -
L2Z30_RS12910 (L2Z30_12910) 2623917..2624183 + 267 WP_000774879.1 hypothetical protein -
L2Z30_RS12915 (L2Z30_12915) 2624226..2624717 - 492 WP_000755583.1 DUF4468 domain-containing protein -
L2Z30_RS12920 (L2Z30_12920) 2624803..2625549 - 747 WP_000599537.1 hypothetical protein -
L2Z30_RS12925 (L2Z30_12925) 2625611..2625994 - 384 WP_000725052.1 hypothetical protein -
L2Z30_RS12930 (L2Z30_12930) 2626059..2626583 - 525 WP_000721574.1 DUF4468 domain-containing protein -
L2Z30_RS12935 (L2Z30_12935) 2626683..2627087 - 405 WP_000966688.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L2Z30_RS12940 (L2Z30_12940) 2627180..2627362 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
L2Z30_RS12945 (L2Z30_12945) 2627688..2628203 - 516 WP_001185585.1 hypothetical protein -
L2Z30_RS12950 (L2Z30_12950) 2628273..2629190 - 918 WP_000094278.1 phage tail tube protein -
L2Z30_RS12955 (L2Z30_12955) 2629243..2630421 - 1179 WP_000002408.1 hypothetical protein -
L2Z30_RS12960 (L2Z30_12960) 2630421..2630774 - 354 WP_000064593.1 hypothetical protein -
L2Z30_RS12965 (L2Z30_12965) 2630843..2631241 - 399 WP_009517131.1 phage tail terminator-like protein -
L2Z30_RS12970 (L2Z30_12970) 2631243..2631611 - 369 WP_002055488.1 hypothetical protein -
L2Z30_RS12975 (L2Z30_12975) 2631583..2631987 - 405 WP_000247948.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2604606..2656428 51822


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T233206 WP_000838146.1 NZ_CP091346:c2627362-2627180 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T233206 NZ_FO704551:c2930344-2930171 [Xenorhabdus poinarii G6]
GTGAAGCAAAGCGAGTTTAGACGGTGGCTGGAAGCTCAAGGTGTCGAAGTTTCAAACGGGACAAACCATCTGAAACTGAA
ATATCAGGGGAAACGAAGCATCATGCCAAGGCACCCCAGCCAAGAGCTAAAAGAGCCACTGAGGAAAGCAATCATTAAGC
AATTAGGATTGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14647.69 Da        Isoelectric Point: 4.4328

>AT233206 WP_000966688.1 NZ_CP091346:c2627087-2626683 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT233206 NZ_FO704551:c2930115-2929699 [Xenorhabdus poinarii G6]
ATGCGATATCCAGTCACACTAGAGCCAGTAGAAGAGGGCGGTTATTTTGTCTCGTTCCCAGATATCCCCGAAGCCTTAAC
GCAAGGGGAGACACGGGAAGAAGCGCTGGAGATGGCACTTGATGCGTTAATCACGTCATTTGAATTTTATTTCGAAGACA
ATGAGAAAATCCCGCTTCCTCGCTCCGTAGGGCGTGATGATGATTATGTCGATGTGCCTTTAAGCGTGGCCTCTAAAGTA
CTGATGCTCAATGCGTTTGTTGATTCTAAGTTAACGCAAACTGAGCTAGCCAGCCGTATGGGGGTGAAAAAGCAGGAAGT
GACACGCATCTTTGACTTACGGCATTCAACCAAGATTGATACGGTAGGTAAGGTCGCGACGGCGATCGGCCATCAATTAA
CTTTGTCTATTGAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S3TWT7


Antitoxin

Source ID Structure
AlphaFold DB N9L2H6

References