Detailed information of TA system TA233191

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 684513..686149
• Replicon: chromosome
• Accession: NZ_CP091335
• Organism: Acinetobacter baumannii strain ATCC17978-VUB

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A1E3M7C1
• Locus tag: L2Z42_RS03360
• Protein ID: WP_000737056.1
• Coordinates: 684513..685844 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: L2Z42_RS03365
• Protein ID: WP_001101308.1
• Coordinates: 685841..686149 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Z42_RS03340 (L2Z42_03340)	680828..681988	+	1161	WP_001044492.1	hypothetical protein	-
L2Z42_RS03345 (L2Z42_03345)	682115..683086	+	972	WP_109104914.1	5'/3'-nucleotidase SurE	-
L2Z42_RS03350 (L2Z42_03350)	683098..683742	+	645	WP_000817301.1	hypothetical protein	-
L2Z42_RS03355 (L2Z42_03355)	683777..684217	-	441	WP_000193135.1	HD domain-containing protein	-
L2Z42_RS03360 (L2Z42_03360)	684513..685844	+	1332	WP_000737056.1	HipA domain-containing protein	Toxin
L2Z42_RS03365 (L2Z42_03365)	685841..686149	+	309	WP_001101308.1	helix-turn-helix domain-containing protein	Antitoxin
L2Z42_RS03370 (L2Z42_03370)	686875..687426	+	552	WP_049594830.1	TetR/AcrR family transcriptional regulator	-
L2Z42_RS03375 (L2Z42_03375)	687642..688262	+	621	WP_000658761.1	hypothetical protein	-
L2Z42_RS03380 (L2Z42_03380)	688280..689362	+	1083	WP_001095788.1	XRE family transcriptional regulator	-
L2Z42_RS03385 (L2Z42_03385)	689404..689904	+	501	WP_240367056.1	hypothetical protein	-
L2Z42_RS03390 (L2Z42_03390)	690066..690584	+	519	WP_000651611.1	GNAT family N-acetyltransferase	-
L2Z42_RS03395 (L2Z42_03395)	690565..690696	+	132	Protein_670	TetR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51189.16 Da
• Isoelectric Point: 4.7456

>T233191 WP_000737056.1 NZ_CP091335:684513-685844 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELDYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNNRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T233191 NZ_FO704550:578713-579024 [Xenorhabdus doucetiae]
ATGTTATTTATTGAAACAAAATTATTTACGGATGATGTAGTTCAGTTACTGACAGATGATGAATACCGCGAATTTCAGGA
GTTTTTGGCTATTCGTCCTGAATTTGGCCAAGTTATCCCTGATACCGGAGGGCTTCGTAAAATTCGATGGGCTTCCTATA
GAACAGGAAAACGTGGTGGTGTGAGAATCATTTATTACTACAAATTATCTGATTCACAAATCAGATTATTGCTAATCTAT
AAAAAAGGGATCAAAGATAATTTAACGGAAAAAGAGAAAAAAATATTACGTAGTCTCAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11626.55 Da
• Isoelectric Point: 9.9701

>AT233191 WP_001101308.1 NZ_CP091335:685841-686149 [Acinetobacter baumannii]
MNVKNQPQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT233191 NZ_FO704550:579025-579315 [Xenorhabdus doucetiae]
ATGGATGCAAAATTGTTTGAGCGTCTGACTGAAAGCATGACGCAAATGAATGAAATTATTGATGGTATTCGCGAACCCTC
TCGCGAAACGCACGTAATTGCTGTACAGGTAAAGCACATTCGTCAATTGACGGGATTGTCCCAGACTGGATTTGCAAAAT
TGATTTCAGTGAATGTTGATACATTGAGGAATTGGGAACAAGGACGCCGTCAGCCTACGGGACCAGCAAAAGCGCTTTTA
CGTGCCATTGAACGTGATCCAGAGCACGTCTTGTTAGCGCTTCAGGTATAA

Structures

Toxin

• AlphaFold DB: A0A1E3M7C1