Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2688444..2689198 Replicon chromosome
Accession NZ_CP091300
Organism Salmonella enterica subsp. enterica serovar Bovismorbificans strain SB699

Toxin (Protein)


Gene name higB Uniprot ID A0A8F2V0H8
Locus tag L1971_RS13810 Protein ID WP_024792370.1
Coordinates 2688444..2688755 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag L1971_RS13815 Protein ID WP_237123685.1
Coordinates 2688752..2689198 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1971_RS13780 (2684102) 2684102..2685004 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
L1971_RS13785 (2685001) 2685001..2685636 + 636 WP_000829028.1 formate dehydrogenase cytochrome b556 subunit -
L1971_RS13790 (2685633) 2685633..2686562 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
L1971_RS13795 (2686609) 2686609..2686899 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
L1971_RS13800 (2686900) 2686900..2687211 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system -
L1971_RS13805 (2687429) 2687429..2688358 + 930 WP_024798833.1 alpha/beta hydrolase -
L1971_RS13810 (2688444) 2688444..2688755 + 312 WP_024792370.1 type II toxin-antitoxin system HigB family toxin Toxin
L1971_RS13815 (2688752) 2688752..2689198 + 447 WP_237123685.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
L1971_RS13820 (2689213) 2689213..2690154 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
L1971_RS13825 (2690199) 2690199..2690636 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
L1971_RS13830 (2690633) 2690633..2691505 - 873 WP_000921423.1 virulence factor BrkB family protein -
L1971_RS13835 (2691499) 2691499..2692098 - 600 WP_000965698.1 glucose-1-phosphatase -
L1971_RS13840 (2692289) 2692289..2693092 - 804 WP_021000967.1 DeoR/GlpR family DNA-binding transcription regulator -
L1971_RS13845 (2693126) 2693126..2694022 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12466.42 Da        Isoelectric Point: 9.5334

>T233092 WP_024792370.1 NZ_CP091300:2688444-2688755 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
VHVISRKPFNEAMLMYPNHELAFTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T233092 NZ_CP128528:1614564-1614833 [Mannheimia haemolytica]
ATGCTACAAATTTCGCCGACAAACGCATATAAAAGAGACTTTAAAAAGATTGCAGCCGAATTAGTCGGTAGTTCGGAATA
TGTGGAAGTAATGTATTGCCTAATAAACCAATTACCATTGGCGGAAAAATATAGAGATCACCCACTACAAGGTGAATGGC
AAGGCTTTAGAGATTGCCATATTAAGCCTGATTTAGTGTTGATTTACGCTGTTGAAGATAATCTGCTCCGCCTTGTTCGT
TTAGGATCGCACGCTGAATTATTTGGATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16716.07 Da        Isoelectric Point: 6.6451

>AT233092 WP_237123685.1 NZ_CP091300:2688752-2689198 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKPPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT233092 NZ_CP128528:1614294-1614560 [Mannheimia haemolytica]
ATGGCGACTATCAATGATGCTTTCAGTTTTAGAACAAATACCGAAATAAAAAATACCGCATTTGATGTAATTAAAAACTA
TGGAATGACACCCTCTCAGGTGTTTAATATGTTTTTAACCGAGATTGCAAAAACGAAAACTATTCCGTTAAGTTTGAATT
ATCAACCCAATCTTGAAACAAAATTGGCAATGCAAGAAGCAAAATCAGGTAAAAATGAAGTTTATGCCTCACTTGAAGCA
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References