Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2235903..2236419 Replicon chromosome
Accession NZ_CP091300
Organism Salmonella enterica subsp. enterica serovar Bovismorbificans strain SB699

Toxin (Protein)


Gene name relE Uniprot ID A0A5I6CHB9
Locus tag L1971_RS11710 Protein ID WP_000220581.1
Coordinates 2235903..2236187 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag L1971_RS11715 Protein ID WP_000212724.1
Coordinates 2236177..2236419 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1971_RS11695 (2231019) 2231019..2232671 + 1653 WP_000155045.1 alpha,alpha-phosphotrehalase -
L1971_RS11700 (2233080) 2233080..2235218 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
L1971_RS11705 (2235435) 2235435..2235899 + 465 WP_024792584.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L1971_RS11710 (2235903) 2235903..2236187 - 285 WP_000220581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1971_RS11715 (2236177) 2236177..2236419 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L1971_RS11720 (2236497) 2236497..2238410 - 1914 WP_024792585.1 BglG family transcription antiterminator -
L1971_RS11725 (2238427) 2238427..2239167 - 741 WP_000779252.1 KDGP aldolase family protein -
L1971_RS11730 (2239164) 2239164..2240282 - 1119 WP_237123910.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
L1971_RS11735 (2240266) 2240266..2241399 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10868.70 Da        Isoelectric Point: 10.0482

>T233090 WP_000220581.1 NZ_CP091300:c2236187-2235903 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T233090 NZ_CP128528:c876695-876513 [Mannheimia haemolytica]
ATGAAATACAGCGAGTTCCTGAGGTACTTACTTGCTCAAGGTTGCGAAATTGAAAACCATAGGCGAGGCAGTCATCGAAA
GGTAACACTAAACGGAAAACAATCGGTTTTTCCTTATCACGGGAGCAAAGAGATTGGTACAGGTTTAGTAAATAAGATTA
AGAAAGACTTAGATCTTAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT233090 WP_000212724.1 NZ_CP091300:c2236419-2236177 [Salmonella enterica subsp. enterica serovar Bovismorbificans]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT233090 NZ_CP128528:c876474-876055 [Mannheimia haemolytica]
ATGTTACGCTACCCAGTTGAAATTACCCCTGATGATAACGGCACATATCTTGTGACTTGCCCTGATATTCCTGAAATGGC
AAGCGTAGGTGAGGACTTAGAAGAAGCCCTATTAGAAGCACAAGATGGCTTAGCCACAGCCCTTGAATTCTATTTTGATG
ATAGACGAGAAATACCAATGCCAAGCCCAATTAAAGAGGGACAACATACGGTTAATCTTACCGTGCTGCAATCAATGAAA
GTATTTCTCTTAAATGAAATGATTAAACAAGGTGTACGCAAAGCAGAAATGGCAAGACGATTAGATGTACACTTACCACA
GATAGATCGCCTATTAGATTTTAATCATTCCACAAAAGTAGAATTTGTTGAGAAAGCCTATGGTAAGCTAAATCAACACT
TTACTATTCTCCCTCACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References