Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 407..1086 Replicon chromosome
Accession NZ_CP091143
Organism Pseudomonas avellanae strain NCPPB 3491

Toxin (Protein)


Gene name vapC Uniprot ID A0A3M5SY82
Locus tag L2Y00_RS00010 Protein ID WP_005620525.1
Coordinates 661..1086 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q48B52
Locus tag L2Y00_RS00005 Protein ID WP_003381346.1
Coordinates 407..664 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y00_RS00005 (L2Y00_00005) 407..664 + 258 WP_003381346.1 Arc family DNA-binding protein Antitoxin
L2Y00_RS00010 (L2Y00_00010) 661..1086 + 426 WP_005620525.1 type II toxin-antitoxin system VapC family toxin Toxin
L2Y00_RS00015 (L2Y00_00015) 1127..1760 + 634 Protein_2 recombinase family protein -
L2Y00_RS00020 (L2Y00_00020) 2035..2904 + 870 WP_229687600.1 AvrD family protein -
L2Y00_RS29845 2897..3076 + 180 WP_259645586.1 AvrD family protein -
L2Y00_RS00025 (L2Y00_00025) 3418..3969 + 552 WP_229687599.1 histidine phosphatase family protein -
L2Y00_RS00030 (L2Y00_00030) 4423..5343 + 921 WP_005620530.1 TauD/TfdA family dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Arc-like DNA binding domain

(5-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15322.67 Da        Isoelectric Point: 4.7010

>T232837 WP_005620525.1 NZ_CP091143:661-1086 [Pseudomonas avellanae]
MILLDTNVISEPQRREPNAHVLDWIDAQALETLYLSTITVAELRAGIALMPVGKRQDSLRENLEKHLLPMFANRVLSFDM
TCTKAYAELLAKSRAAGLAVETADAFIAAIAIALANGFTVATRDTGPFEAAGLNVINPWEA

Download         Length: 426 bp

>T232837 NZ_CP128261:2352206-2352490 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAAATGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGTTACGGGAACGTCTTGAAAACCCTCGGGTTCCGGCTTCGCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9401.62 Da        Isoelectric Point: 9.0330

>AT232837 WP_003381346.1 NZ_CP091143:407-664 [Pseudomonas avellanae]
VANVNVRNLPDEVHRAIRIQAALHGRSTEAEIRDILERAARPEGRVKLGSFLASIAREVGGLTDKEHTLFENTRITSPAR
AVSFE

Download         Length: 258 bp

>AT232837 NZ_CP128261:2351968-2352216 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3M5SY82

Antitoxin

Source ID Structure
AlphaFold DB Q48B52

References