Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 55183..55718 Replicon chromosome
Accession NZ_CP091125
Organism Serratia marcescens strain CM2015_854

Toxin (Protein)


Gene name relE Uniprot ID A0A854J4R0
Locus tag L2D47_RS00250 Protein ID WP_038875945.1
Coordinates 55443..55718 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5P6GNG1
Locus tag L2D47_RS00245 Protein ID WP_038875948.1
Coordinates 55183..55443 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D47_RS00225 (L2D47_00225) 50503..51153 + 651 WP_047729554.1 DcrB-related protein -
L2D47_RS00230 (L2D47_00230) 51194..51799 + 606 WP_038875954.1 glutathione S-transferase -
L2D47_RS00235 (L2D47_00235) 51868..53262 + 1395 WP_047729550.1 L-seryl-tRNA(Sec) selenium transferase -
L2D47_RS00240 (L2D47_00240) 53259..55100 + 1842 WP_055311812.1 selenocysteine-specific translation elongation factor -
L2D47_RS00245 (L2D47_00245) 55183..55443 + 261 WP_038875948.1 ribbon-helix-helix domain-containing protein Antitoxin
L2D47_RS00250 (L2D47_00250) 55443..55718 + 276 WP_038875945.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2D47_RS00255 (L2D47_00255) 55730..56641 - 912 WP_055311811.1 LysR family transcriptional regulator -
L2D47_RS00260 (L2D47_00260) 56763..57389 + 627 WP_055311810.1 LysE family translocator -
L2D47_RS00265 (L2D47_00265) 57442..58689 - 1248 WP_038875940.1 MFS transporter -
L2D47_RS00270 (L2D47_00270) 58907..59899 + 993 WP_055311809.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10548.34 Da        Isoelectric Point: 10.6099

>T232804 WP_038875945.1 NZ_CP091125:55443-55718 [Serratia marcescens]
MALKWTSKALSDLARLFEFLALANRTVAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T232804 NZ_CP128255:765493-765867 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTTCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9667.98 Da        Isoelectric Point: 4.5201

>AT232804 WP_038875948.1 NZ_CP091125:55183-55443 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT232804 NZ_CP128255:765039-765404 [Escherichia coli]
GTGTCAGACACACTGCCCGGGACAACGCATCCCGACAACAACAACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGATGCC
CTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGTTCA
GCGACGCGGATTCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGTGAA
CTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTGTGG
TTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854J4R0

Antitoxin

Source ID Structure
AlphaFold DB A0A5P6GNG1

References