Detailed information of TA system TA023278

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ygfYX/Cpta(toxin)
• Location: 3697106..3697775
• Replicon: chromosome
• Accession: NC_011663
• Organism: Shewanella baltica OS223

Toxin (Protein)

• Gene name: ygfX
• Uniprot ID: B8EBR0
• Locus tag: SBAL223_RS15950
• Protein ID: WP_012588261.1
• Coordinates: 3697106..3697546 (-)
• Length: 147 a.a.

Antitoxin (Protein)

• Gene name: ygfY
• Uniprot ID: -
• Locus tag: SBAL223_RS15955
• Protein ID: WP_006080770.1
• Coordinates: 3697527..3697775 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL223_RS15925	3692591..3693064	-	474	WP_006080776.1	SoxR reducing system RseC family protein	-
SBAL223_RS15930	3693075..3694007	-	933	WP_006080775.1	MucB/RseB C-terminal domain-containing protein	-
SBAL223_RS15935	3694020..3694646	-	627	WP_006080774.1	anti-sigma factor	-
SBAL223_RS15940	3694688..3695266	-	579	WP_006080773.1	RNA polymerase sigma factor RpoE	-
SBAL223_RS15945	3695456..3697069	+	1614	WP_006080772.1	L-aspartate oxidase	-
SBAL223_RS15950	3697106..3697546	-	441	WP_012588261.1	hypothetical protein	Toxin
SBAL223_RS15955	3697527..3697775	-	249	WP_006080770.1	succinate dehydrogenase assembly factor 2	Antitoxin
SBAL223_RS15960	3697861..3698769	-	909	WP_006080769.1	transcriptional activator NhaR	-
SBAL223_RS15965	3698842..3699228	-	387	WP_006080768.1	hypothetical protein	-
SBAL223_RS15970	3699231..3700400	-	1170	WP_006080767.1	Na+/H+ antiporter NhaA	-
SBAL223_RS15975	3700518..3701312	-	795	WP_006080766.1	thymidylate synthase	-
SBAL223_RS15980	3701309..3702118	-	810	WP_006080765.1	prolipoprotein diacylglyceryl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (6-135)

Antitoxin

• Flavinator of succinate dehydrogenase (7-77)

Sequences

Toxin

Protein

• Length: 147 a.a.
• Molecular weight: 17358.45 Da
• Isoelectric Point: 7.7165

>T23278 WP_012588261.1 NC_011663:c3697546-3697106 [Shewanella baltica OS223]
VEDRHHSFILKASFDQRLSLVVFFCVCSSSFLLWPQSDNLALSLLKYLFILLVCVFLLSQLWRLQHWRLDFVLSDKGEGR
LSTGEHFQVLKRTWVTPFVCLMYIEVDTQLRLLMVWADMLDDTDYRHLCRLLLRAKIQQTKPHTEI

Nucleotide

• Length: 441 bp

>T23278 NC_011663:c3697546-3697106 [Shewanella baltica OS223]
GTGGAAGACCGGCACCATAGTTTCATCTTAAAAGCCTCCTTCGACCAACGACTCTCGTTGGTCGTTTTTTTTTGTGTCTG
TTCTAGCTCATTTTTACTCTGGCCCCAGAGCGATAATCTCGCCTTATCCCTGCTTAAATATCTGTTTATCCTGCTAGTTT
GTGTTTTCTTGCTATCACAGTTGTGGCGACTGCAGCATTGGCGTTTAGATTTTGTGCTTAGTGATAAAGGCGAGGGACGT
TTGTCAACGGGTGAGCACTTTCAGGTATTAAAGCGAACTTGGGTGACCCCCTTTGTTTGCTTGATGTATATCGAAGTGGA
TACTCAGTTGCGGCTCTTGATGGTTTGGGCGGATATGCTAGACGATACTGACTATCGGCATTTATGTCGGCTGTTGCTGC
GGGCTAAAATACAACAGACTAAACCTCATACTGAGATTTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9723.36 Da
• Isoelectric Point: 4.4929

>AT23278 WP_006080770.1 NC_011663:c3697775-3697527 [Shewanella baltica OS223]
MELMNIARVRWACRRGMLELDVLFQPFVENFYQEMSDEDKTVFIRLLECEDPELFAWFMGHEVCPDAELARMVVKVRGRP
AP

Nucleotide

• Length: 249 bp

>AT23278 NC_011663:c3697775-3697527 [Shewanella baltica OS223]
TTGGAATTAATGAACATCGCAAGGGTTCGCTGGGCATGTCGCCGCGGGATGCTGGAATTAGACGTTTTGTTTCAACCTTT
TGTTGAAAACTTCTATCAAGAAATGTCCGATGAAGATAAAACCGTGTTTATCCGTTTGTTGGAATGTGAAGATCCCGAAT
TGTTTGCATGGTTTATGGGCCATGAAGTTTGCCCTGATGCTGAACTCGCGCGTATGGTAGTGAAAGTCCGTGGAAGACCG
GCACCATAG

Structures

Toxin

• AlphaFold DB: B8EBR0