Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4968797..4969313 Replicon chromosome
Accession NZ_CP091061
Organism Klebsiella pneumoniae strain KP29105

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag L1062_RS23945 Protein ID WP_004178374.1
Coordinates 4968797..4969081 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag L1062_RS23950 Protein ID WP_002886901.1
Coordinates 4969071..4969313 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1062_RS23920 (4964193) 4964193..4964456 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
L1062_RS23925 (4964586) 4964586..4964759 + 174 WP_041169004.1 hypothetical protein -
L1062_RS23930 (4964762) 4964762..4965505 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
L1062_RS23935 (4965862) 4965862..4968000 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
L1062_RS23940 (4968329) 4968329..4968793 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L1062_RS23945 (4968797) 4968797..4969081 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L1062_RS23950 (4969071) 4969071..4969313 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L1062_RS23955 (4969391) 4969391..4971301 - 1911 WP_012737231.1 PRD domain-containing protein -
L1062_RS23960 (4971324) 4971324..4972478 - 1155 WP_012737230.1 lactonase family protein -
L1062_RS23965 (4972545) 4972545..4973285 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T232603 WP_004178374.1 NZ_CP091061:c4969081-4968797 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T232603 NZ_CP127405:c166159-164837 [Stenotrophomonas sp. As-7]
ATGGGTACGTTGCGGGTCTGGATGAATGGTGTCGAGGTAGCGCTCTGGGATGATGCGCGGAACCGGGCATCCCGCCTTTC
CTACCTCAGCCAATGGATTGGTTCGACGCAGTCGCGACCGCTGTCCCTTTCGCTCCCCCTGCTGCCCGACGGTGAAAGCC
ATCAAGGTCAGGTGGTCAACGACTACTTCGACAATCTTCTCCCCGATAACGTCACCATCCGCAACCGGATCCGCGACCGG
TTCGCCACGCGCAGCAGCAATACGTTCGATCTGCTTGAAGCCATTGGCCGGGATTGTGTGGGCGCGGTGCAGCTGTTGCC
ACATTCGCGCACACCGGATGCCATCCAGCGGATAACGTTCGAACCATTGAATGACTCAGGCGTCGCTGAAGTCCTGCGCC
AGGTCACAACAAGTGCATTGCCTGGCACTTCTTCCAGCGACGATGCGTTCCGCATTTCCATCGCTGGAGCGCAGGAAAAG
ACCGGCCTGCTGCTGCACGATGGTCAATGGTGCATTCCTACCGGAAGTACGCCGTCCACGCACATCTTCAAGCTGCCGTT
GGGTATCGTCGGCAACATGCGTGCGGACATGCACCAGTCCGTGGAGAACGAGTGGCTGTGCATGCACCTGCTGGCAGCCT
TTGGAATTCCCGTCGCGGATACGCAGATGGGGCGTTTTGAAGATCAAGGTGCACTGATCGTCGAACGTTTCGACCGGCGA
CTGGCTGCGGATCGCGTGTGGTGGCTTCGCTTGCCGCAGGAAGATATGTGTCAGGTCTTTGGCCTCCCCGCTGCCCGGAA
GTACGAATCCGATGGCGGCCCCGGCATCGTGGCCATCATGGATCTGCTTCGGCAATCCGAGCAGCCTGAGGATCGAGCAA
CCTTCTTCAAGACGCAGATCCTGTTCTGGATGCTTGCCGCGACCGACGGCCACGCAAAGAACTTCAGCGTCCACATCGAC
GCGGGTGGGCGTTTCCGTCTGACTCCTGTCTACGACGTGCTGTCGGTATATCCCATCCTCGGCCGGGGGCCCAATCAACT
CGATCCGCACAACGCGCAGCTTGCCATGGCGGTAGAGGGCAAGAACCGCCATCGAAAACTGCATCTTGTGCGACGCCGGC
ACTGGAACGAAACCGCACGTGCCTGTGGCGTAGCCGATGGCGCAGAGCCATGGATCGAAGCGTTGATCGCTTCCGTGGAG
CCCGCCATCGAACACGTCACACGCCAGCTTCCAAGCGGCTTCCCTTCGACCGTGTCCGAACCTGTTTTCAAGGGACTGCG
TGCTGCGGCGACCCGCCTTTCCAGCATGGCCCCCGACGCCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT232603 WP_002886901.1 NZ_CP091061:c4969313-4969071 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT232603 NZ_CP127405:c166420-166163 [Stenotrophomonas sp. As-7]
ATGGACAGGCCGCCGCATACGGTGAGAACACCGCAGCAACTTGCGCCGCTGATGCGCGCGTTCAGACGCCAGGCCGGGCT
GAGTCAAGCACAGCTTGCCGAGCGACTGGGCATCTCCCGCCAGGCAGTCGGCGCATTGGAACGCGATCCAGCGTCTGCCA
GCTTCGAGCGATTGATGCGAGTCTGGGCCGTGTTGGGCCTGGAAATCAGCCTGCAGCAGCGAAGTCCCCGGGAAAACACG
TCGACTTCGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References