Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3945815..3946643 Replicon chromosome
Accession NZ_CP091024
Organism Escherichia coli strain STEC379

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag L1P13_RS19575 Protein ID WP_235399408.1
Coordinates 3945815..3946192 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag L1P13_RS19580 Protein ID WP_235399409.1
Coordinates 3946275..3946643 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1P13_RS19545 (3941399) 3941399..3942718 + 1320 WP_000144688.1 site-specific integrase -
L1P13_RS19550 (3942811) 3942811..3943098 - 288 Protein_3834 DUF4942 domain-containing protein -
L1P13_RS19555 (3943380) 3943380..3944384 - 1005 WP_001179707.1 IS110-like element ISSfl8 family transposase -
L1P13_RS19560 (3944456) 3944456..3945016 - 561 Protein_3836 DUF4942 domain-containing protein -
L1P13_RS19565 (3945113) 3945113..3945310 - 198 WP_000772024.1 DUF957 domain-containing protein -
L1P13_RS19570 (3945330) 3945330..3945818 - 489 WP_032215286.1 DUF5983 family protein -
L1P13_RS19575 (3945815) 3945815..3946192 - 378 WP_235399408.1 TA system toxin CbtA family protein Toxin
L1P13_RS19580 (3946275) 3946275..3946643 - 369 WP_235399409.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
L1P13_RS19585 (3946806) 3946806..3947027 - 222 WP_137446885.1 DUF987 domain-containing protein -
L1P13_RS19590 (3947090) 3947090..3947566 - 477 WP_001186747.1 RadC family protein -
L1P13_RS19595 (3947582) 3947582..3948055 - 474 WP_001696846.1 antirestriction protein -
L1P13_RS19600 (3948149) 3948149..3948394 - 246 WP_000680586.1 hypothetical protein -
L1P13_RS19605 (3948394) 3948394..3949212 - 819 WP_089581163.1 DUF932 domain-containing protein -
L1P13_RS19610 (3949552) 3949552..3950622 - 1071 WP_109955363.1 patatin-like phospholipase family protein -
L1P13_RS19615 (3950619) 3950619..3951524 - 906 WP_001696852.1 diguanylate cyclase regulator RdcB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3943380..3944384 1004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14305.36 Da        Isoelectric Point: 8.7198

>T232435 WP_235399408.1 NZ_CP091024:c3946192-3945815 [Escherichia coli]
MKTLPDTHVRKASRCPSPVTVWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYQEAKR

Download         Length: 378 bp

>T232435 NZ_CP127297:2842773-2844095 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13652.47 Da        Isoelectric Point: 6.7392

>AT232435 WP_235399409.1 NZ_CP091024:c3946643-3946275 [Escherichia coli]
VSDKLSGITHPDDNHDRSWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT232435 NZ_CP127297:2842507-2842773 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References