Detailed information of TA system TA232418

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 819122..819957
• Replicon: chromosome
• Accession: NZ_CP091024
• Organism: Escherichia coli strain STEC379

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: L1P13_RS03975
• Protein ID: WP_032286705.1
• Coordinates: 819122..819499 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: L1P13_RS03980
• Protein ID: WP_235399448.1
• Coordinates: 819589..819957 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1P13_RS03950 (815014)	815014..815550	+	537	WP_000942795.1	GspM family type II secretion system protein YghD	-
L1P13_RS03955 (815885)	815885..817420	-	1536	WP_032286710.1	EAL domain-containing protein	-
L1P13_RS03960 (817491)	817491..818339	-	849	Protein_778	DUF4942 domain-containing protein	-
L1P13_RS03965 (818428)	818428..818625	-	198	WP_000839243.1	DUF957 domain-containing protein	-
L1P13_RS03970 (818637)	818637..819125	-	489	WP_235399447.1	DUF5983 family protein	-
L1P13_RS03975 (819122)	819122..819499	-	378	WP_032286705.1	TA system toxin CbtA family protein	Toxin
L1P13_RS03980 (819589)	819589..819957	-	369	WP_235399448.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
L1P13_RS03985 (820120)	820120..820341	-	222	WP_000692345.1	DUF987 domain-containing protein	-
L1P13_RS03990 (820404)	820404..820880	-	477	WP_001186727.1	RadC family protein	-
L1P13_RS03995 (820896)	820896..821381	-	486	WP_160392016.1	antirestriction protein	-
L1P13_RS04000 (821436)	821436..822253	-	818	Protein_786	DUF945 domain-containing protein	-
L1P13_RS04005 (822353)	822353..822586	-	234	WP_001119729.1	DUF905 family protein	-
L1P13_RS04010 (822665)	822665..823120	-	456	WP_000581504.1	IrmA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13991.96 Da
• Isoelectric Point: 7.8045

>T232418 WP_032286705.1 NZ_CP091024:c819499-819122 [Escherichia coli]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPEAKQ

Nucleotide

• Length: 378 bp

>T232418 NZ_CP127277:3532245-3532589 [Mycobacterium tuberculosis]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13582.36 Da
• Isoelectric Point: 6.6255

>AT232418 WP_235399448.1 NZ_CP091024:c819957-819589 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYSTPETKK

Nucleotide

• Length: 369 bp

>AT232418 NZ_CP127277:3532586-3532915 [Mycobacterium tuberculosis]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCGGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA