Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 740163..740856 Replicon chromosome
Accession NZ_CP091020
Organism Escherichia coli strain STEC308

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag L1O95_RS03620 Protein ID WP_000415584.1
Coordinates 740163..740459 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag L1O95_RS03625 Protein ID WP_000650107.1
Coordinates 740461..740856 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1O95_RS03590 (735838) 735838..736152 - 315 WP_000958598.1 putative quinol monooxygenase -
L1O95_RS03595 (736183) 736183..736764 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
L1O95_RS03600 (736874) 736874..738223 - 1350 WP_000673406.1 quorum sensing histidine kinase QseC -
L1O95_RS03605 (738220) 738220..738879 - 660 WP_001221491.1 quorum sensing response regulator transcription factor QseB -
L1O95_RS03610 (739031) 739031..739423 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
L1O95_RS03615 (739476) 739476..739958 + 483 WP_000183494.1 GyrI-like domain-containing protein -
L1O95_RS03620 (740163) 740163..740459 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
L1O95_RS03625 (740461) 740461..740856 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
L1O95_RS03630 (740989) 740989..742596 + 1608 WP_001324265.1 ABC transporter substrate-binding protein -
L1O95_RS03635 (742734) 742734..744992 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - rfaE / gspC / gspD / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / iroB / vipA/tssB / vipB/tssC / hcp/tssD / clpV/tssH 691941..900248 208307


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T232361 WP_000415584.1 NZ_CP091020:740163-740459 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T232361 NZ_CP127276:3755754-3756011 [Mycobacterium tuberculosis]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT232361 WP_000650107.1 NZ_CP091020:740461-740856 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT232361 NZ_CP127276:3755482-3755757 [Mycobacterium tuberculosis]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References