Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4695151..4695983 Replicon chromosome
Accession NZ_CP091016
Organism Escherichia coli strain STEC306

Toxin (Protein)


Gene name yeeV Uniprot ID A0A346GNK2
Locus tag L1O96_RS23720 Protein ID WP_032082789.1
Coordinates 4695609..4695983 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M2U6P5
Locus tag L1O96_RS23715 Protein ID WP_001774606.1
Coordinates 4695151..4695519 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1O96_RS23670 (4690183) 4690183..4690863 + 681 WP_032082725.1 WYL domain-containing protein -
L1O96_RS23675 (4691011) 4691011..4691688 + 678 WP_001097305.1 hypothetical protein -
L1O96_RS23680 (4691694) 4691694..4691927 + 234 WP_001278287.1 DUF905 family protein -
L1O96_RS23685 (4692026) 4692026..4692844 + 819 WP_044154198.1 DUF932 domain-containing protein -
L1O96_RS23690 (4692844) 4692844..4693089 + 246 WP_032082791.1 hypothetical protein -
L1O96_RS23695 (4693183) 4693183..4693662 + 480 WP_032082790.1 antirestriction protein -
L1O96_RS23700 (4693678) 4693678..4694154 + 477 WP_001297237.1 RadC family protein -
L1O96_RS23705 (4694217) 4694217..4694438 + 222 WP_000692312.1 DUF987 domain-containing protein -
L1O96_RS23710 (4694457) 4694457..4695101 + 645 WP_001774605.1 hypothetical protein -
L1O96_RS23715 (4695151) 4695151..4695519 + 369 WP_001774606.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
L1O96_RS23720 (4695609) 4695609..4695983 + 375 WP_032082789.1 TA system toxin CbtA family protein Toxin
L1O96_RS23725 (4695980) 4695980..4696468 + 489 WP_032082788.1 DUF5983 family protein -
L1O96_RS23730 (4696485) 4696485..4696682 + 198 WP_032082787.1 DUF957 domain-containing protein -
L1O96_RS23735 (4696779) 4696779..4697624 + 846 WP_032082786.1 DUF4942 domain-containing protein -
L1O96_RS23740 (4697695) 4697695..4699230 + 1536 WP_001609560.1 EAL domain-containing protein -
L1O96_RS23745 (4699433) 4699433..4700545 - 1113 WP_001300563.1 IS4-like element IS421 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14214.29 Da        Isoelectric Point: 8.2905

>T232327 WP_032082789.1 NZ_CP091016:4695609-4695983 [Escherichia coli]
MKTLPDTHVREASRCPPPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRTTGLMTRDNYRTVNNITLSKHPEKR

Download         Length: 375 bp

>T232327 NZ_CP127276:1383757-1384188 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.31 Da        Isoelectric Point: 5.8746

>AT232327 WP_001774606.1 NZ_CP091016:4695151-4695519 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT232327 NZ_CP127276:1383500-1383760 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A346GNK2

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2U6P5

References