232289

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 782756..783265 Replicon chromosome
Accession NZ_CP091006
Organism Staphylococcus epidermidis strain R10C

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag KB224_RS03620 Protein ID WP_001829980.1
Coordinates 783056..783265 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag KB224_RS03615 Protein ID WP_001829893.1
Coordinates 782756..783049 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KB224_RS03590 (KB224_03590) 777764..778552 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
KB224_RS03595 (KB224_03595) 778558..779196 + 639 WP_002505076.1 thiamine phosphate synthase -
KB224_RS03600 (KB224_03600) 779285..780157 + 873 WP_002458703.1 membrane protein insertase YidC -
KB224_RS03605 (KB224_03605) 780263..780916 - 654 WP_001829983.1 HD domain-containing protein -
KB224_RS03610 (KB224_03610) 781098..782582 - 1485 WP_235063538.1 cardiolipin synthase -
KB224_RS03615 (KB224_03615) 782756..783049 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
KB224_RS03620 (KB224_03620) 783056..783265 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
KB224_RS03625 (KB224_03625) 783408..783545 + 138 WP_194376625.1 Lmo0850 family protein -
KB224_RS03630 (KB224_03630) 783644..784855 - 1212 WP_002486299.1 FtsW/RodA/SpoVE family cell cycle protein -
KB224_RS03635 (KB224_03635) 785246..786319 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
KB224_RS03640 (KB224_03640) 786331..787686 + 1356 WP_002470674.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T232289 WP_001829980.1 NZ_CP091006:783056-783265 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T232289 NZ_CP127275:2847969-2848346 [Mycobacterium tuberculosis]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT232289 WP_001829893.1 NZ_CP091006:782756-783049 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT232289 NZ_CP127275:2847715-2847972 [Mycobacterium tuberculosis]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References