Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1588518..1589186 Replicon chromosome
Accession NZ_CP090888
Organism Streptococcus pneumoniae strain PT8465

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag L1A19_RS07970 Protein ID WP_001132284.1
Coordinates 1589007..1589186 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag L1A19_RS07965 Protein ID WP_000961810.1
Coordinates 1588518..1588970 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A19_RS07940 (L1A19_07940) 1584408..1585151 - 744 WP_001188199.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
L1A19_RS07945 (L1A19_07945) 1585153..1586103 - 951 WP_000451132.1 50S ribosomal protein L11 methyltransferase -
L1A19_RS07950 (L1A19_07950) 1586241..1586669 - 429 WP_000418176.1 NUDIX hydrolase -
L1A19_RS07955 (L1A19_07955) 1586635..1587738 - 1104 WP_000719717.1 site-2 protease family protein -
L1A19_RS07960 (L1A19_07960) 1587757..1588227 - 471 WP_000257106.1 DUF3013 family protein -
L1A19_RS07965 (L1A19_07965) 1588518..1588970 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L1A19_RS07970 (L1A19_07970) 1589007..1589186 - 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
L1A19_RS07975 (L1A19_07975) 1589323..1589502 - 180 WP_001809903.1 hypothetical protein -
L1A19_RS07980 (L1A19_07980) 1589667..1589906 - 240 WP_000818078.1 hypothetical protein -
L1A19_RS07985 (L1A19_07985) 1590176..1591447 + 1272 WP_049479613.1 replication-associated recombination protein A -
L1A19_RS07995 (L1A19_07995) 1591992..1593311 - 1320 WP_000502545.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T232071 WP_001132284.1 NZ_CP090888:c1589186-1589007 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T232071 NZ_CP127237:53921-54403 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT232071 WP_000961810.1 NZ_CP090888:c1588970-1588518 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT232071 NZ_CP127237:53667-53933 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References