Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1640230..1640898 Replicon chromosome
Accession NZ_CP090881
Organism Streptococcus pneumoniae strain BR1268

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag L1A11_RS08415 Protein ID WP_001132285.1
Coordinates 1640719..1640898 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4J1XUY0
Locus tag L1A11_RS08410 Protein ID WP_000961812.1
Coordinates 1640230..1640682 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1A11_RS08385 (L1A11_08385) 1636120..1636863 - 744 WP_001188204.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
L1A11_RS08390 (L1A11_08390) 1636865..1637815 - 951 WP_000451160.1 50S ribosomal protein L11 methyltransferase -
L1A11_RS08395 (L1A11_08395) 1637953..1638381 - 429 WP_000418157.1 NUDIX hydrolase -
L1A11_RS08400 (L1A11_08400) 1638362..1639450 - 1089 WP_000719712.1 site-2 protease family protein -
L1A11_RS08405 (L1A11_08405) 1639469..1639939 - 471 WP_000257088.1 DUF3013 family protein -
L1A11_RS08410 (L1A11_08410) 1640230..1640682 - 453 WP_000961812.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L1A11_RS08415 (L1A11_08415) 1640719..1640898 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
L1A11_RS08420 (L1A11_08420) 1641035..1641283 - 249 WP_000797237.1 hypothetical protein -
L1A11_RS08425 (L1A11_08425) 1641273..1641512 - 240 WP_000818079.1 hypothetical protein -
L1A11_RS08430 (L1A11_08430) 1641782..1643053 + 1272 WP_001113213.1 replication-associated recombination protein A -
L1A11_RS08440 (L1A11_08440) 1643473..1644600 - 1128 WP_000323403.1 tyrosine-type recombinase/integrase -
L1A11_RS08445 (L1A11_08445) 1644602..1644784 - 183 WP_000655518.1 DUF3173 domain-containing protein -
L1A11_RS08450 (L1A11_08450) 1644800..1645843 - 1044 WP_001031659.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T232042 WP_001132285.1 NZ_CP090881:c1640898-1640719 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T232042 NZ_CP127229:1032568-1032786 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT232042 WP_000961812.1 NZ_CP090881:c1640682-1640230 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGLTVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT232042 NZ_CP127229:1032167-1032541 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A4J1XUY0

References