Detailed information of TA system TA023197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 302983..303803
• Replicon: chromosome
• Accession: NC_011415
• Organism: Escherichia coli SE11

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: ECSE_RS01405
• Protein ID: WP_001054379.1
• Coordinates: 303546..303803 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: ECSE_RS01400
• Protein ID: WP_000123955.1
• Coordinates: 302983..303534 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECSE_RS01380	298579..299067	+	489	WP_000815953.1	hypothetical protein	-
ECSE_RS01385	299064..301025	+	1962	WP_000695187.1	DUF3732 domain-containing protein	-
ECSE_RS26285	301118..301688	+	571	Protein_262	integrase core domain-containing protein	-
ECSE_RS01390	301806..302057	-	252	WP_000077643.1	hypothetical protein	-
ECSE_RS01395	302185..302931	-	747	WP_000354253.1	methyltransferase domain-containing protein	-
ECSE_RS01400	302983..303534	-	552	WP_000123955.1	N-acetyltransferase	Antitoxin
ECSE_RS01405	303546..303803	-	258	WP_001054379.1	YjhX family toxin	Toxin
ECSE_RS01410	304130..305392	-	1263	WP_000351410.1	PTS galactitol transporter subunit IIC	-
ECSE_RS01415	305481..306476	-	996	WP_000649881.1	2-hydroxyacid dehydrogenase	-
ECSE_RS01420	306493..307254	-	762	WP_000365307.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T23197 WP_001054379.1 NC_011415:c303803-303546 [Escherichia coli SE11]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T23197 NC_011415:c303803-303546 [Escherichia coli SE11]
ATGAATTTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGACGTATTGCACACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTACCGCATCAACACCACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20294.30 Da
• Isoelectric Point: 6.2120

>AT23197 WP_000123955.1 NC_011415:c303534-302983 [Escherichia coli SE11]
MTAHHFTFHITDESDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARHEGKAVGHILFTLATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGLLIRTGIEHLRQMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT23197 NC_011415:c303534-302983 [Escherichia coli SE11]
ATGACAGCACACCACTTCACTTTTCATATCACAGACGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCTCTGCTGGCCC
GACATGAAGGTAAAGCCGTCGGACATATTTTATTTACCCTAGCGACGTTCAAAGGAGAAATGGATTCACCTCTGATGCAT
ATCCTTGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTAGGCGGTTTGCTGATACGTACAGGCATAGAACA
CCTGAGGCAGATGGGCTGCCAGACGGTTTTTGTTCTCGGTCACGCTACCTATTACCCACGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCAGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030