Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 2156082..2156935 Replicon chromosome
Accession NZ_CP090790
Organism Bifidobacterium longum strain D2TC

Toxin (Protein)


Gene name relE Uniprot ID A0A7L9UL57
Locus tag LMY38_RS09270 Protein ID WP_029679475.1
Coordinates 2156444..2156935 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V6XX41
Locus tag LMY38_RS09265 Protein ID WP_008783109.1
Coordinates 2156082..2156444 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMY38_RS09260 (LMY38_09260) 2153237..2155936 + 2700 WP_032683088.1 aconitate hydratase AcnA -
LMY38_RS09265 (LMY38_09265) 2156082..2156444 + 363 WP_008783109.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LMY38_RS09270 (LMY38_09270) 2156444..2156935 + 492 WP_029679475.1 PIN domain-containing protein Toxin
LMY38_RS09275 (LMY38_09275) 2156996..2159101 - 2106 WP_013140894.1 DUF262 domain-containing protein -
LMY38_RS09280 (LMY38_09280) 2159190..2159831 - 642 WP_029679476.1 GNAT family N-acetyltransferase -
LMY38_RS09285 (LMY38_09285) 2159872..2160012 - 141 Protein_1797 LuxR C-terminal-related transcriptional regulator -
LMY38_RS09290 (LMY38_09290) 2160296..2161198 + 903 WP_032683087.1 Bax inhibitor-1/YccA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18370.95 Da        Isoelectric Point: 4.5590

>T231895 WP_029679475.1 NZ_CP090790:2156444-2156935 [Bifidobacterium longum]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCVSLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDRAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

>T231895 NZ_CP126987:c4742301-4742017 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 13974.03 Da        Isoelectric Point: 5.0733

>AT231895 WP_008783109.1 NZ_CP090790:2156082-2156444 [Bifidobacterium longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDAYYNMKRAD

Download         Length: 363 bp

>AT231895 NZ_CP126987:c4742533-4742291 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L9UL57

Antitoxin

Source ID Structure
AlphaFold DB V6XX41

References