Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 481713..482352 Replicon chromosome
Accession NZ_CP090786
Organism Burkholderia vietnamiensis strain 2003Ycf867

Toxin (Protein)


Gene name vapC Uniprot ID A0A132DRA7
Locus tag L0Y95_RS02150 Protein ID WP_011883463.1
Coordinates 481933..482352 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A132DHM6
Locus tag L0Y95_RS02145 Protein ID WP_011883461.1
Coordinates 481713..481946 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y95_RS02135 (L0Y95_02135) 478279..480642 + 2364 WP_011883458.1 xanthine dehydrogenase molybdopterin binding subunit -
L0Y95_RS02140 (L0Y95_02140) 480730..481386 + 657 WP_249471491.1 xanthine dehydrogenase accessory protein XdhC -
L0Y95_RS02145 (L0Y95_02145) 481713..481946 + 234 WP_011883461.1 DNA-binding protein Antitoxin
L0Y95_RS02150 (L0Y95_02150) 481933..482352 + 420 WP_011883463.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Y95_RS02155 (L0Y95_02155) 482482..482883 + 402 WP_011883465.1 polyketide cyclase -
L0Y95_RS02160 (L0Y95_02160) 482924..483868 - 945 WP_059461581.1 LysR family transcriptional regulator -
L0Y95_RS02165 (L0Y95_02165) 483938..484576 - 639 WP_046426269.1 2-hydroxychromene-2-carboxylate isomerase -
L0Y95_RS02170 (L0Y95_02170) 484671..486104 - 1434 WP_212180766.1 TAXI family TRAP transporter solute-binding subunit -
L0Y95_RS02175 (L0Y95_02175) 486573..486929 + 357 WP_011883473.1 BON domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15649.85 Da        Isoelectric Point: 6.0999

>T231889 WP_011883463.1 NZ_CP090786:481933-482352 [Burkholderia vietnamiensis]
MFLVDTNVISEVRKRERADKGVMAFFRKAAQDDADLYLSVVTVGELRRGVEIIRHRGDKSQATRLENWLDGVLREFASNI
LAVDEEIGQLWGRLRVPHPEHSLDKLIAATALIHDLIVVTRNVDDFAGTGARVLNPFES

Download         Length: 420 bp

>T231889 NZ_CP126987:1454281-1454697 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATTATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACCGACATCCGGGTGGCGCTGCACCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCTGGACTGACACTGG
AAGACTGGGTTATTTAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8379.44 Da        Isoelectric Point: 5.0644

>AT231889 WP_011883461.1 NZ_CP090786:481713-481946 [Burkholderia vietnamiensis]
MATLLVRNVDEELVQSLRERAAANGRSAEAEHREILAKALRAPQRKTFAQVLMSIPNVGTDADFARVDDGEAANVFG

Download         Length: 234 bp

>AT231889 NZ_CP126987:1454054-1454284 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A132DRA7

Antitoxin

Source ID Structure
AlphaFold DB A0A132DHM6

References