Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 929413..931160 | Replicon | chromosome |
| Accession | NZ_CP090778 | ||
| Organism | Burkholderia multivorans strain 2005Ycf971III | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | B9BHC0 |
| Locus tag | L0Y92_RS06320 | Protein ID | WP_006403210.1 |
| Coordinates | 929413..930309 (+) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | B9AZJ2 |
| Locus tag | L0Y92_RS06325 | Protein ID | WP_006396780.1 |
| Coordinates | 930306..931160 (+) | Length | 285 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Y92_RS06290 (L0Y92_06290) | 924812..925891 | - | 1080 | WP_006409825.1 | porin | - |
| L0Y92_RS06295 (L0Y92_06295) | 926328..926645 | + | 318 | WP_006396774.1 | non-heme iron oxygenase ferredoxin subunit | - |
| L0Y92_RS06300 (L0Y92_06300) | 926647..926958 | + | 312 | WP_006403207.1 | hypothetical protein | - |
| L0Y92_RS06305 (L0Y92_06305) | 927006..928076 | + | 1071 | WP_006403208.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| L0Y92_RS06310 (L0Y92_06310) | 928069..928839 | + | 771 | WP_006408452.1 | SDR family oxidoreductase | - |
| L0Y92_RS06315 (L0Y92_06315) | 928867..929394 | + | 528 | WP_006396778.1 | cupin domain-containing protein | - |
| L0Y92_RS06320 (L0Y92_06320) | 929413..930309 | + | 897 | WP_006403210.1 | alpha/beta fold hydrolase | Toxin |
| L0Y92_RS06325 (L0Y92_06325) | 930306..931160 | + | 855 | WP_006396780.1 | IclR family transcriptional regulator | Antitoxin |
| L0Y92_RS06330 (L0Y92_06330) | 931157..931954 | + | 798 | WP_006409174.1 | SDR family oxidoreductase | - |
| L0Y92_RS06335 (L0Y92_06335) | 931947..933614 | + | 1668 | WP_006403211.1 | thiamine pyrophosphate-binding protein | - |
| L0Y92_RS06340 (L0Y92_06340) | 933607..934437 | + | 831 | WP_006403212.1 | aspartate dehydrogenase | - |
| L0Y92_RS06345 (L0Y92_06345) | 934499..935989 | + | 1491 | WP_006403213.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30544.80 Da Isoelectric Point: 8.0446
>T231873 WP_006403210.1 NZ_CP090778:929413-930309 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQQAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQQAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA
Download Length: 897 bp
>T231873 NZ_CP126978:115716-116012 [Gallibacterium anatis]
ATGATTCAGATAAAATCAACAGAAACCTTTGATAAATGGCTAGATAATCTCAAGGATTTAAGGGCAAGGGCTAAAATTCA
AGTGCGGATTAAACGATTACAGCTTGGCAATTTTGGTGATGTAAAGCCGATAGGTGAAGGGTTATCTGAATTAAGAATAA
CAGAAGGGAAAGGCTACCGTCTGTACTTGAAAAATCAGAATGGGGTGATTGTGATTTTGTTATGCGGTGGTGACAAATCC
ACACAGAAAGCGGATATTGAAAAGGCAAAATCTTTAGCAAAAGAGTTAGGAGTTTAG
ATGATTCAGATAAAATCAACAGAAACCTTTGATAAATGGCTAGATAATCTCAAGGATTTAAGGGCAAGGGCTAAAATTCA
AGTGCGGATTAAACGATTACAGCTTGGCAATTTTGGTGATGTAAAGCCGATAGGTGAAGGGTTATCTGAATTAAGAATAA
CAGAAGGGAAAGGCTACCGTCTGTACTTGAAAAATCAGAATGGGGTGATTGTGATTTTGTTATGCGGTGGTGACAAATCC
ACACAGAAAGCGGATATTGAAAAGGCAAAATCTTTAGCAAAAGAGTTAGGAGTTTAG
Antitoxin
Download Length: 285 a.a. Molecular weight: 31176.75 Da Isoelectric Point: 6.6558
>AT231873 WP_006396780.1 NZ_CP090778:930306-931160 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 855 bp
>AT231873 NZ_CP126978:116014-116298 [Gallibacterium anatis]
ATGGTTGAGAAATTACACGATTTTGATATGTCCGAACATTTACGCACAGAAGAAGAAATACAGCTTTATCTTAATGAGAT
TTTAAGTGAGGGTGATATTGATTTATTGCTTTCTGCGTTAGGTGATATAGCGAAAGCGAGAAATATGAGTCAAATTGCCC
GAGAAGTAGGAATAACGAGAGAAGGGTTATATAAAGCGCTTTCTGGGCGAGGCAATCCCACATTTGCCACTGTGTTTAAG
GTCATGCAGGCGTTAAACTTGAATTTAGAAGTAAAACACGCTTAA
ATGGTTGAGAAATTACACGATTTTGATATGTCCGAACATTTACGCACAGAAGAAGAAATACAGCTTTATCTTAATGAGAT
TTTAAGTGAGGGTGATATTGATTTATTGCTTTCTGCGTTAGGTGATATAGCGAAAGCGAGAAATATGAGTCAAATTGCCC
GAGAAGTAGGAATAACGAGAGAAGGGTTATATAAAGCGCTTTCTGGGCGAGGCAATCCCACATTTGCCACTGTGTTTAAG
GTCATGCAGGCGTTAAACTTGAATTTAGAAGTAAAACACGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|