231840

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 772631..773322 Replicon chromosome
Accession NZ_CP090765
Organism Burkholderia multivorans strain 2008Ycf542

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y85_RS03280 Protein ID WP_065496260.1
Coordinates 772867..773322 (+) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Y85_RS03275 Protein ID WP_065496259.1
Coordinates 772631..772870 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y85_RS03250 (L0Y85_03250) 767692..767835 - 144 WP_006409932.1 hypothetical protein -
L0Y85_RS03255 (L0Y85_03255) 768424..768627 + 204 WP_006396646.1 hypothetical protein -
L0Y85_RS03260 (L0Y85_03260) 768641..769324 - 684 WP_105835359.1 Fe2+-dependent dioxygenase -
L0Y85_RS03265 (L0Y85_03265) 769321..770076 - 756 WP_175848494.1 tetratricopeptide repeat protein -
L0Y85_RS03270 (L0Y85_03270) 770080..772326 - 2247 WP_012216643.1 TonB-dependent siderophore receptor -
L0Y85_RS03275 (L0Y85_03275) 772631..772870 + 240 WP_065496259.1 Arc family DNA-binding protein Antitoxin
L0Y85_RS03280 (L0Y85_03280) 772867..773322 + 456 WP_065496260.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Y85_RS03285 (L0Y85_03285) 773419..774714 - 1296 WP_035487510.1 aspartate carbamoyltransferase -
L0Y85_RS03290 (L0Y85_03290) 774947..775081 + 135 WP_006396654.1 entericidin A/B family lipoprotein -
L0Y85_RS03295 (L0Y85_03295) 775174..775743 - 570 WP_105835361.1 permease -
L0Y85_RS03300 (L0Y85_03300) 775939..776889 - 951 WP_175848493.1 DMT family transporter -
L0Y85_RS03305 (L0Y85_03305) 777481..778275 - 795 WP_105835364.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16209.56 Da        Isoelectric Point: 7.2060

>T231840 WP_065496260.1 NZ_CP090765:772867-773322 [Burkholderia multivorans]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK

Download         Length: 456 bp

>T231840 NZ_CP126961:1227061-1227906 [Streptococcus anginosus]
ATGAACAAAGCTAAATTAACAGCACTCTGTCATAAAATATCAAAGAATACTGGTTTAACCTTTAATTCCGTGATGACCTA
TTACTTCCTAGAAGTCATTTTGAAAAAATTAAGTCAAAGTTCTTATTCAAATCACTATATCTTCAAAGGAGGATTCCTAC
TGTCGAATGTCATCGGAGTTGAATCTCGTAGCACTGTTGATATTGACTTTTTATTCCATCAAATAACACTCTCAGAAGAA
ACTGTTAAACAGCAACTCAAGGAAATTTTAGCAGATTCCGAAGAAGGTATATCTTTTGTGATTCAATCAATCACAACTAT
TAAAGAAAGTGATGACTATGGTGGCTATCGAGCAACAATTTCGTGCCAACTTGAGAATATTAAACAAGTTATCCATTTGG
ATATTGCGACAGGTGATGTTGTAACTCCTCAGCCGATAACATACGACTATAAAGCTATTTTTGATGAAGACAATTTTCCA
ATCATTGCTTATACAATTGAAACAATTCTAGCTGAAAAACTCCAAACCATCTATTCACGAAACTTCTTGAACAGCAGAAG
CAAAGACTTTTACGATGTTTATATTCTTTCAAAATTGAAGAAAAAAGATATTGATTTCAATCAGTTAAAAAATGCTTGCC
AAAGAACTTTTTCCTATCGCGAAACTGAGCTCGATTTCGAAAAAATTATTGAACTACTCGAGAGATTCAAATCTGATCCT
ACTCAGAATCAACAATGGCAAAAATATTCAAAAAAATATAGTTATACAAAAGGAATTTCACTTGCAAATGTGCTTGATGA
GATGATTAGTCTTATTACAATTATTATTTCTACTGACTCTGATTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8750.96 Da        Isoelectric Point: 5.1133

>AT231840 WP_065496259.1 NZ_CP090765:772631-772870 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDFDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT231840 NZ_CP126961:1226474-1227064 [Streptococcus anginosus]
ATGTCAAAAAAAGAGATTCTACTCGATTTTATAGAAAAGAACAATAGCATTGTCACAAACAAAGATTGTAAAGCACTAGG
TATTCCAACAATATATCTGACAAGACTAGAGAAAGAAGGCATTATCTTCCGAGTTGAAAAAGGTATTTTCCTAACCCAAA
ACGGAGACTATGATGAATACTACTTCTTTCAATATCGTTTTCCTAAGGCTATTTTCTCTTATATTTCGGCACTGTATCTA
CAACAGTTTACAGATGAAATTCCACAATATTTTGATGTGACAGTTCCTAGAGGCTACCGCTTTAATACTCCTCCAGCTAA
TCTAAACATTCACTTTGTCTCTAAAGAATACAGCGAGCTGGGAATGACTACTGTACCTACTCCTATGGGAAACAACGTAA
GGGTATATGATTTTGAACGTATTATTTGTGATTTTGTAATACATCGAGAAAAGATTGATTCCGAACTCTTTGTCAAGACA
CTTCAATCTTATGGGAACTATCCTAAAAAAAATCTAGCAAAACTCTATGAATATGCGACAAAAATGAATACTTTAGAAAA
AGTTAAACAAACTCTGGAGGTTCTAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References