Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 791834..792423 Replicon chromosome
Accession NZ_CP090758
Organism Burkholderia multivorans strain 2010Ycf31III

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z13_RS22180 Protein ID WP_006409935.1
Coordinates 792004..792423 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z13_RS22175 Protein ID WP_174328801.1
Coordinates 791834..792007 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z13_RS22150 (L0Z13_22150) 786916..787059 - 144 WP_006409932.1 hypothetical protein -
L0Z13_RS22155 (L0Z13_22155) 787648..787851 + 204 WP_006403067.1 hypothetical protein -
L0Z13_RS22160 (L0Z13_22160) 787865..788548 - 684 WP_006409924.1 Fe2+-dependent dioxygenase -
L0Z13_RS22165 (L0Z13_22165) 788545..789300 - 756 WP_006403069.1 tetratricopeptide repeat protein -
L0Z13_RS22170 (L0Z13_22170) 789304..791550 - 2247 WP_006403070.1 TonB-dependent siderophore receptor -
L0Z13_RS22175 (L0Z13_22175) 791834..792007 + 174 WP_174328801.1 plasmid stability protein Antitoxin
L0Z13_RS22180 (L0Z13_22180) 792004..792423 + 420 WP_006409935.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z13_RS22185 (L0Z13_22185) 792556..793851 - 1296 WP_035487510.1 aspartate carbamoyltransferase -
L0Z13_RS22190 (L0Z13_22190) 794084..794218 + 135 WP_006409923.1 entericidin A/B family lipoprotein -
L0Z13_RS22195 (L0Z13_22195) 794312..794887 - 576 WP_006409927.1 hypothetical protein -
L0Z13_RS22200 (L0Z13_22200) 795091..796041 - 951 WP_172488721.1 DMT family transporter -
L0Z13_RS22205 (L0Z13_22205) 796554..797348 - 795 WP_006409930.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15146.38 Da        Isoelectric Point: 5.2157

>T231819 WP_006409935.1 NZ_CP090758:792004-792423 [Burkholderia multivorans]
MILVDTNVIFEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AAGKAYARIRAHARAVGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAS

Download         Length: 420 bp

>T231819 NZ_CP126955:c2439807-2439704 [Escherichia coli O78:H4]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6298.07 Da        Isoelectric Point: 4.5184

>AT231819 WP_174328801.1 NZ_CP090758:791834-792007 [Burkholderia multivorans]
MHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTRTDPMSFE

Download         Length: 174 bp

>AT231819 NZ_CP126955:2439666-2439937 [Escherichia coli O78:H4]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References