Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 3362717..3363354 Replicon chromosome
Accession NZ_CP090757
Organism Burkholderia multivorans strain 2010Ycf31III

Toxin (Protein)


Gene name vapC Uniprot ID A0A8E2UU98
Locus tag L0Z13_RS18580 Protein ID WP_035489546.1
Coordinates 3362717..3363118 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A132EWB1
Locus tag L0Z13_RS18585 Protein ID WP_006408845.1
Coordinates 3363118..3363354 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z13_RS18570 (L0Z13_18570) 3360038..3361180 + 1143 WP_006408286.1 alginate lyase family protein -
L0Z13_RS18575 (L0Z13_18575) 3361207..3362595 + 1389 WP_006408285.1 L-serine ammonia-lyase -
L0Z13_RS18580 (L0Z13_18580) 3362717..3363118 - 402 WP_035489546.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z13_RS18585 (L0Z13_18585) 3363118..3363354 - 237 WP_006408845.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
L0Z13_RS18590 (L0Z13_18590) 3363542..3365245 + 1704 WP_006408280.1 thiamine pyrophosphate-binding protein -
L0Z13_RS18595 (L0Z13_18595) 3365242..3366330 + 1089 WP_006408279.1 hypothetical protein -
L0Z13_RS18600 (L0Z13_18600) 3366449..3367480 - 1032 WP_045594318.1 helix-turn-helix domain-containing protein -
L0Z13_RS18605 (L0Z13_18605) 3367651..3368193 - 543 WP_006408276.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15035.28 Da        Isoelectric Point: 5.7429

>T231817 WP_035489546.1 NZ_CP090757:c3363118-3362717 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTLCTNPARERRNLAALIEDIPVAPFDVAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Download         Length: 402 bp

>T231817 NZ_CP126955:c1808043-1807936 [Escherichia coli O78:H4]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8915.00 Da        Isoelectric Point: 5.8651

>AT231817 WP_006408845.1 NZ_CP090757:c3363354-3363118 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Download         Length: 237 bp

>AT231817 NZ_CP126955:1808090-1808156 [Escherichia coli O78:H4]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A132EWB1

References