Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 901168..902915 Replicon chromosome
Accession NZ_CP090754
Organism Burkholderia multivorans strain 2010Ycf41

Toxin (Protein)


Gene name doc Uniprot ID B9BHC0
Locus tag L0Z40_RS19685 Protein ID WP_006403210.1
Coordinates 901168..902064 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B9AZJ2
Locus tag L0Z40_RS19690 Protein ID WP_006396780.1
Coordinates 902061..902915 (+) Length 285 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z40_RS19655 (L0Z40_19655) 896567..897646 - 1080 WP_006409825.1 porin -
L0Z40_RS19660 (L0Z40_19660) 898083..898400 + 318 WP_053298416.1 non-heme iron oxygenase ferredoxin subunit -
L0Z40_RS19665 (L0Z40_19665) 898402..898713 + 312 WP_053298417.1 hypothetical protein -
L0Z40_RS19670 (L0Z40_19670) 898761..899831 + 1071 WP_065496357.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
L0Z40_RS19675 (L0Z40_19675) 899824..900594 + 771 WP_105752056.1 SDR family oxidoreductase -
L0Z40_RS19680 (L0Z40_19680) 900622..901149 + 528 WP_006396778.1 cupin domain-containing protein -
L0Z40_RS19685 (L0Z40_19685) 901168..902064 + 897 WP_006403210.1 alpha/beta fold hydrolase Toxin
L0Z40_RS19690 (L0Z40_19690) 902061..902915 + 855 WP_006396780.1 IclR family transcriptional regulator Antitoxin
L0Z40_RS19695 (L0Z40_19695) 902912..903709 + 798 WP_006409174.1 SDR family oxidoreductase -
L0Z40_RS19700 (L0Z40_19700) 903702..905369 + 1668 WP_053298420.1 thiamine pyrophosphate-binding protein -
L0Z40_RS19705 (L0Z40_19705) 905362..906192 + 831 WP_006403212.1 aspartate dehydrogenase -
L0Z40_RS19710 (L0Z40_19710) 906254..907744 + 1491 WP_105799370.1 aldehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(51-280)

Antitoxin

(23-71)


Sequences


Toxin        


Download         Length: 299 a.a.        Molecular weight: 30544.80 Da        Isoelectric Point: 8.0446

>T231811 WP_006403210.1 NZ_CP090754:901168-902064 [Burkholderia multivorans]
MSVVDKRERDRTAAFATLLERFPEQRCAAGAAGTIGYREAGAQQAGAALPVVLLHGIGSGAASWVRQLDALGASRRVLAW
DAPGYGASTPVHGASPSAVDYAASLDAWLDALGIARCVLVGHSLGAIVAGGMVRVKPERIAGLLLISPAGGYGSAPAETR
ASRRDARLAMLAELGPAGLAAQRSGNMLSGFATEDARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAGVGLQVIPQAGHAGYVEAPDVYSALIDAFCRQCDIERRAA

Download         Length: 897 bp

>T231811 NZ_CP126954:110123-110401 [Escherichia coli O78:H4]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31176.75 Da        Isoelectric Point: 6.6558

>AT231811 WP_006396780.1 NZ_CP090754:902061-902915 [Burkholderia multivorans]
MSEPLQSAAEPAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYKL
GIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSEAPVFSSIRVNVGTRLPAHATTHGHV
LMGDLSLDELRALYPEGTLPRMTNATPDTVDALYTMIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVPR
PEIDATLIADGLIDKVRRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 855 bp

>AT231811 NZ_CP126954:109854-110123 [Escherichia coli O78:H4]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTGGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAAGTCGCCGGTAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB B9BHC0


Antitoxin

Source ID Structure
AlphaFold DB B9AZJ2

References