Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 60350..60996 Replicon plasmid p1_2010Ycf503
Accession NZ_CP090750
Organism Burkholderia multivorans strain 2010Ycf503

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z02_RS29080 Protein ID WP_012211060.1
Coordinates 60589..60996 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z02_RS29075 Protein ID WP_009692911.1
Coordinates 60350..60592 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z02_RS29060 (L0Z02_29060) 56553..57596 - 1044 WP_105770427.1 ParB/RepB/Spo0J family partition protein -
L0Z02_RS29065 (L0Z02_29065) 57593..58279 - 687 WP_009692909.1 ParA family partition ATPase -
L0Z02_RS29070 (L0Z02_29070) 59268..60248 + 981 WP_249469137.1 non-homologous end-joining DNA ligase -
L0Z02_RS29075 (L0Z02_29075) 60350..60592 + 243 WP_009692911.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L0Z02_RS29080 (L0Z02_29080) 60589..60996 + 408 WP_012211060.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z02_RS29085 (L0Z02_29085) 61340..62563 + 1224 WP_176159119.1 hypothetical protein -
L0Z02_RS29090 (L0Z02_29090) 62560..62862 + 303 WP_244143159.1 hypothetical protein -
L0Z02_RS29095 (L0Z02_29095) 62873..63181 + 309 WP_105770425.1 hypothetical protein -
L0Z02_RS29100 (L0Z02_29100) 63178..63900 + 723 WP_105770424.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..106647 106647


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(12-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14613.77 Da        Isoelectric Point: 5.1402

>T231802 WP_012211060.1 NZ_CP090750:60589-60996 [Burkholderia multivorans]
MSLYLLDTNILSNVIRDPRGACASRIGETRPEQVCTSIVVAAELRYGVCKRGSSALAQRVEQLLASLTVLPLQSDADQCY
GRLRADLERQGQLIGANDMLIAAHAMAVDAVLVTDNTAEFTRVTGLAVENWLRPA

Download         Length: 408 bp

>T231802 NZ_CP126952:4452356-4452613 [Escherichia coli O78:H4]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9309.54 Da        Isoelectric Point: 4.8615

>AT231802 WP_009692911.1 NZ_CP090750:60350-60592 [Burkholderia multivorans]
MPTHDTRHARLFRNGRSQAVRIPREFELPVSEVTIHREGRRLIIEPVEAPSLRELFAQWAPLDETFPDIENLPAEPVDIE

Download         Length: 243 bp

>AT231802 NZ_CP126952:4452625-4453170 [Escherichia coli O78:H4]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCGGTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References