Detailed information of TA system TA231798

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1125324..1126023
• Replicon: chromosome
• Accession: NZ_CP090748
• Organism: Burkholderia multivorans strain 2010Ycf503

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: L0Z02_RS21345
• Protein ID: WP_053298526.1
• Coordinates: 1125324..1125620 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: B9BI88
• Locus tag: L0Z02_RS21350
• Protein ID: WP_006403504.1
• Coordinates: 1125622..1126023 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z02_RS21330 (L0Z02_21330)	1122049..1123590	+	1542	WP_249468759.1	sensor domain-containing diguanylate cyclase	-
L0Z02_RS21335 (L0Z02_21335)	1123797..1124069	+	273	WP_006403506.1	hypothetical protein	-
L0Z02_RS21340 (L0Z02_21340)	1124170..1125204	+	1035	WP_249468760.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
L0Z02_RS21345 (L0Z02_21345)	1125324..1125620	+	297	WP_053298526.1	type II toxin-antitoxin system MqsR family toxin	Toxin
L0Z02_RS21350 (L0Z02_21350)	1125622..1126023	+	402	WP_006403504.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
L0Z02_RS21355 (L0Z02_21355)	1126313..1126873	+	561	WP_249468762.1	GNAT family N-acetyltransferase	-
L0Z02_RS21360 (L0Z02_21360)	1126938..1127879	+	942	WP_035487669.1	ABC transporter substrate-binding protein	-
L0Z02_RS21365 (L0Z02_21365)	1127911..1128972	+	1062	WP_065496516.1	LLM class flavin-dependent oxidoreductase	-
L0Z02_RS21370 (L0Z02_21370)	1128969..1130321	+	1353	WP_006409061.1	LLM class flavin-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11173.06 Da
• Isoelectric Point: 9.1122

>T231798 WP_053298526.1 NZ_CP090748:1125324-1125620 [Burkholderia multivorans]
MEKRTAHCKLPRVKALIEAGKVRLTASAVIGARQMGFTEAETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T231798 NZ_CP126952:c3651965-3651663 [Escherichia coli O78:H4]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.68 Da
• Isoelectric Point: 7.0834

>AT231798 WP_006403504.1 NZ_CP090748:1125622-1126023 [Burkholderia multivorans]
MKCPACGAATLVRDTRDIPYTYKGESTVIPHITGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT231798 NZ_CP126952:c3651627-3651286 [Escherichia coli O78:H4]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Structures

Antitoxin

• AlphaFold DB: B9BI88