Detailed information of TA system TA231738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 83414..84051
• Replicon: chromosome
• Accession: NZ_CP090730
• Organism: Burkholderia cepacia strain 2011Ycf793I

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: U2FRJ0
• Locus tag: L0Z05_RS00365
• Protein ID: WP_021164186.1
• Coordinates: 83650..84051 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: L0Z05_RS00360
• Protein ID: WP_042978332.1
• Coordinates: 83414..83650 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Z05_RS00345 (L0Z05_00345)	78913..79944	+	1032	WP_042978041.1	helix-turn-helix domain-containing protein	-
L0Z05_RS00350 (L0Z05_00350)	80220..81332	-	1113	WP_249452841.1	ADP-heptose--LPS heptosyltransferase	-
L0Z05_RS00355 (L0Z05_00355)	81329..83032	-	1704	WP_249452835.1	thiamine pyrophosphate-binding protein	-
L0Z05_RS00360 (L0Z05_00360)	83414..83650	+	237	WP_042978332.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L0Z05_RS00365 (L0Z05_00365)	83650..84051	+	402	WP_021164186.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Z05_RS00370 (L0Z05_00370)	84119..85507	-	1389	WP_021164187.1	L-serine ammonia-lyase	-
L0Z05_RS00375 (L0Z05_00375)	85538..86674	-	1137	WP_249452833.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15033.14 Da
• Isoelectric Point: 5.2050

>T231738 WP_021164186.1 NZ_CP090730:83650-84051 [Burkholderia cepacia]
MPRYMLDTNMCIYLMKHQPEQVAKRFAQCYTGDVVMSAITYAELEYGVAACANAVRERRNLADLIEDIPVAPFDAAAAQA
YGPVREATRERKRDHLDKLIAAHAVSLDVVLVTNNERDFASYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T231738 NZ_CP126946:c3264374-3263976 [Escherichia coli O78:H51]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8926.06 Da
• Isoelectric Point: 5.1651

>AT231738 WP_042978332.1 NZ_CP090730:83414-83650 [Burkholderia cepacia]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPVRRPLAGVLEKFAKFAPDFMAEGRGDQEQADREGL

Nucleotide

• Length: 237 bp

>AT231738 NZ_CP126946:c3264601-3264374 [Escherichia coli O78:H51]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Structures

Toxin

• AlphaFold DB: U2FRJ0