Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 83008..83654 Replicon plasmid p1_2016Y70888756VI
Accession NZ_CP090706
Organism Burkholderia multivorans strain 2016Y70888756VI

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z41_RS29230 Protein ID WP_009692912.1
Coordinates 83008..83415 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z41_RS29235 Protein ID WP_009692911.1
Coordinates 83412..83654 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z41_RS29205 (L0Z41_29205) 79815..80546 - 732 WP_084752453.1 hypothetical protein -
L0Z41_RS29210 (L0Z41_29210) 80543..80851 - 309 WP_084752450.1 hypothetical protein -
L0Z41_RS29215 (L0Z41_29215) 81032..81640 - 609 WP_241277291.1 hypothetical protein -
L0Z41_RS29220 (L0Z41_29220) 81672..81992 - 321 WP_084752448.1 hypothetical protein -
L0Z41_RS29225 (L0Z41_29225) 82335..82865 - 531 WP_156908368.1 hypothetical protein -
L0Z41_RS29230 (L0Z41_29230) 83008..83415 - 408 WP_009692912.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Z41_RS29235 (L0Z41_29235) 83412..83654 - 243 WP_009692911.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L0Z41_RS29490 83641..83889 - 249 WP_252447792.1 hypothetical protein -
L0Z41_RS29495 83910..84260 - 351 WP_252447791.1 hypothetical protein -
L0Z41_RS29245 (L0Z41_29245) 84286..84600 - 315 WP_241277290.1 hypothetical protein -
L0Z41_RS29250 (L0Z41_29250) 85441..86127 + 687 WP_249463523.1 ParA family partition ATPase -
L0Z41_RS29255 (L0Z41_29255) 86124..87167 + 1044 WP_069301928.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..115999 115999


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(12-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14506.64 Da        Isoelectric Point: 4.8230

>T231683 WP_009692912.1 NZ_CP090706:c83415-83008 [Burkholderia multivorans]
MSLYLLDTNILSNVIRDPRGACASRIGETPPEQVCTSIVVAAELRYGVCKRGSSALAQRVEQLLASLTVLPLQSDADQCY
GRLRADLERQGQLIGANDMLIAAHALAVDAVLVTDNTAEFTRVAGLAVENWLRPA

Download         Length: 408 bp

>T231683 NZ_CP126942:4174563-4174715 [Escherichia coli O1:K1:H7]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9309.54 Da        Isoelectric Point: 4.8615

>AT231683 WP_009692911.1 NZ_CP090706:c83654-83412 [Burkholderia multivorans]
MPTHDTRHARLFRNGRSQAVRIPREFELPVSEVTIHREGRRLIIEPVEAPSLRELFAQWAPLDETFPDIENLPAEPVDIE

Download         Length: 243 bp

>AT231683 NZ_CP126942:c4174514-4174457 [Escherichia coli O1:K1:H7]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References