Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 564724..565994 Replicon chromosome
Accession NZ_CP090696
Organism Burkholderia multivorans strain 2017Y71078597II

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Z09_RS18370 Protein ID WP_105774903.1
Coordinates 564724..565302 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Z09_RS18375 Protein ID WP_217085942.1
Coordinates 565437..565994 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Z09_RS18350 (L0Z09_18350) 560012..560803 + 792 WP_065496148.1 enoyl-CoA hydratase -
L0Z09_RS18355 (L0Z09_18355) 560800..561939 + 1140 WP_006410588.1 enoyl-CoA hydratase/isomerase family protein -
L0Z09_RS18360 (L0Z09_18360) 561986..562906 - 921 WP_065496151.1 LysR family transcriptional regulator -
L0Z09_RS18365 (L0Z09_18365) 563085..564623 + 1539 WP_249462417.1 MFS transporter -
L0Z09_RS18370 (L0Z09_18370) 564724..565302 - 579 WP_105774903.1 HD domain-containing protein Toxin
L0Z09_RS18375 (L0Z09_18375) 565437..565994 - 558 WP_217085942.1 helix-turn-helix transcriptional regulator Antitoxin
L0Z09_RS18380 (L0Z09_18380) 566507..567910 + 1404 WP_088929364.1 hypothetical protein -
L0Z09_RS18385 (L0Z09_18385) 567921..568541 - 621 WP_006410617.1 isochorismatase family cysteine hydrolase -
L0Z09_RS18390 (L0Z09_18390) 569132..569575 - 444 WP_223852633.1 antibiotic biosynthesis monooxygenase -
L0Z09_RS18395 (L0Z09_18395) 569675..570700 - 1026 WP_006406131.1 aldo/keto reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21461.19 Da        Isoelectric Point: 5.2986

>T231649 WP_105774903.1 NZ_CP090696:c565302-564724 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALHGIDTLKLLKLCVVHDLGEALHGDIP
APEQAAHPDKNMHERDDLLTLTAALDPVLRNELVALWDEYDVAASPEARAAKALDKLETILQHTQGANPPDFDYAFNLDY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAHT

Download         Length: 579 bp

>T231649 NZ_CP126940:2065884-2066138 [Escherichia coli O2:K1:H7]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20304.26 Da        Isoelectric Point: 8.1964

>AT231649 WP_217085942.1 NZ_CP090696:c565994-565437 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAELFGVAQSTISRWEAGVQQMSPDERATAERLLAAHLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLSMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCRWTRIMLSGGAAARLVETL

Download         Length: 558 bp

>AT231649 NZ_CP126940:2065636-2065887 [Escherichia coli O2:K1:H7]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References