Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1959986..1960444 Replicon chromosome
Accession NZ_CP090689
Organism Burkholderia multivorans strain 2017Y71087112III

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L0Y89_RS19610 Protein ID WP_244131008.1
Coordinates 1959986..1960156 (+) Length 57 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L0Y89_RS19615 Protein ID WP_105825892.1
Coordinates 1960160..1960444 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y89_RS19590 (L0Y89_19590) 1955368..1956468 - 1101 WP_006413771.1 chorismate synthase -
L0Y89_RS19595 (L0Y89_19595) 1956637..1958571 - 1935 WP_105778678.1 MFS transporter -
L0Y89_RS19600 (L0Y89_19600) 1958720..1959175 - 456 WP_006402096.1 CBS domain-containing protein -
L0Y89_RS19605 (L0Y89_19605) 1959336..1959653 + 318 WP_006402097.1 DUF962 domain-containing protein -
L0Y89_RS19610 (L0Y89_19610) 1959986..1960156 + 171 WP_244131008.1 hypothetical protein Toxin
L0Y89_RS19615 (L0Y89_19615) 1960160..1960444 + 285 WP_105825892.1 putative addiction module antidote protein Antitoxin
L0Y89_RS19620 (L0Y89_19620) 1960528..1960716 + 189 WP_105837111.1 hypothetical protein -
L0Y89_RS19625 (L0Y89_19625) 1960883..1962211 - 1329 WP_039224705.1 YihY family inner membrane protein -
L0Y89_RS19630 (L0Y89_19630) 1962356..1962967 + 612 WP_105837110.1 NAD(P)H:quinone oxidoreductase -
L0Y89_RS19635 (L0Y89_19635) 1962964..1963359 + 396 WP_088926186.1 DUF2069 domain-containing protein -
L0Y89_RS19640 (L0Y89_19640) 1963378..1964799 + 1422 WP_105837109.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-53)

Antitoxin

Uncharacterized protein HI1420

(5-90)


Sequences

Toxin        


Download         Length: 57 a.a.        Molecular weight: 6450.50 Da        Isoelectric Point: 8.4800

>T231636 WP_244131008.1 NZ_CP090689:1959986-1960156 [Burkholderia multivorans]
VLDEGVCELKIDFGPGYRVYYVRRGEVVYLLLCGGDKSTQRKDVKRAVQMARELKE

Download         Length: 171 bp

>T231636 NZ_CP126937:4030225-4030377 [Escherichia coli O2:K1:H4]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10013.45 Da        Isoelectric Point: 6.7229

>AT231636 WP_105825892.1 NZ_CP090689:1960160-1960444 [Burkholderia multivorans]
MTNYTEFDAADYLDNDEAVAEFLAVAAEDPNPDVFLAAVAAVARARGMTKVAAAAGVGRVALHKALTPGAHPRYETVQKI
IRSLGLRMSFKVAH

Download         Length: 285 bp

>AT231636 NZ_CP126937:c4030176-4030119 [Escherichia coli O2:K1:H4]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References