Detailed information of TA system TA231592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 3281974..3282611
• Replicon: chromosome
• Accession: NZ_CP090673
• Organism: Burkholderia multivorans strain 2020Y71628512IV

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A8E2UU98
• Locus tag: L0Y82_RS25700
• Protein ID: WP_035489546.1
• Coordinates: 3281974..3282375 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: A0A132EWB1
• Locus tag: L0Y82_RS25705
• Protein ID: WP_006408845.1
• Coordinates: 3282375..3282611 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L0Y82_RS25690 (L0Y82_25695)	3279295..3280437	+	1143	WP_006408286.1	alginate lyase family protein	-
L0Y82_RS25695 (L0Y82_25700)	3280464..3281852	+	1389	WP_006408285.1	L-serine ammonia-lyase	-
L0Y82_RS25700 (L0Y82_25705)	3281974..3282375	-	402	WP_035489546.1	type II toxin-antitoxin system VapC family toxin	Toxin
L0Y82_RS25705 (L0Y82_25710)	3282375..3282611	-	237	WP_006408845.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L0Y82_RS25710 (L0Y82_25715)	3282799..3284502	+	1704	WP_006408280.1	thiamine pyrophosphate-binding protein	-
L0Y82_RS25715 (L0Y82_25720)	3284499..3285587	+	1089	WP_006408279.1	hypothetical protein	-
L0Y82_RS25720 (L0Y82_25725)	3285706..3286737	-	1032	WP_045594318.1	helix-turn-helix domain-containing protein	-
L0Y82_RS25725 (L0Y82_25730)	3286908..3287450	-	543	WP_006408276.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-121)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 15035.28 Da
• Isoelectric Point: 5.7429

>T231592 WP_035489546.1 NZ_CP090673:c3282375-3281974 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTLCTNPARERRNLAALIEDIPVAPFDVAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNNERDFASYPGLRLENWLIG

Nucleotide

• Length: 402 bp

>T231592 NZ_CP126932:135244-135531 [Escherichia coli O78:H51]
ATGACTTATACGGTAAAATTCAGGGATGATGCGCTCAAGGAATGGCTGAAACTGGATAAGACCATTCAACAACAGTTTGT
GAAAAAACTAAAAAAATGCAGCGAAAATCCTCATATACCGTCAGCAAAACTAAGAGGGCTAAAGGATTGCTACAAAATTA
AACTACGTGCATCGGGATTTCGTCTGGTTTATCAGGTGATTGACGATATGTTAATTATTGCGGTTGTTGCGGTAGGAAAA
CGAGAACGTAGTAACGTTTATAATCTCGCCAGTGAGAGAATGAGATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8915.00 Da
• Isoelectric Point: 5.8651

>AT231592 WP_006408845.1 NZ_CP090673:c3282611-3282375 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREGW

Nucleotide

• Length: 237 bp

>AT231592 NZ_CP126932:134996-135247 [Escherichia coli O78:H51]
ATGCCTAACATCATTCTGTCTGACACCAGTGCAAGTGTCAGTGAACTGAAAAAAAATCCTATGGCTACAGTCAGTGCCGG
AGATGGTTACCCTGTCGCCATTCTTAACCGGAATCAGCCGGCATTCTACTGTGTGCCTGCTGAACTGTATGAAAGGATGC
TTGATGCTCTGGATGACCAGGAACTGGTGAAACTGGTTACTGAACGCAGCAATCAGCCACTGCATGATGTGGACCTAGAC
AGTTATTTATGA

Structures

Antitoxin

• AlphaFold DB: A0A132EWB1