Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 791901..792490 Replicon chromosome
Accession NZ_CP090672
Organism Burkholderia multivorans strain 2020Y71628512IV

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L0Y82_RS03265 Protein ID WP_006409935.1
Coordinates 792071..792490 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L0Y82_RS03260 Protein ID WP_174328801.1
Coordinates 791901..792074 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Y82_RS03235 (L0Y82_03235) 786983..787126 - 144 WP_006409932.1 hypothetical protein -
L0Y82_RS03240 (L0Y82_03240) 787715..787918 + 204 WP_006403067.1 hypothetical protein -
L0Y82_RS03245 (L0Y82_03245) 787932..788615 - 684 WP_006409924.1 Fe2+-dependent dioxygenase -
L0Y82_RS03250 (L0Y82_03250) 788612..789367 - 756 WP_006403069.1 tetratricopeptide repeat protein -
L0Y82_RS03255 (L0Y82_03255) 789371..791617 - 2247 WP_006403070.1 TonB-dependent siderophore receptor -
L0Y82_RS03260 (L0Y82_03260) 791901..792074 + 174 WP_174328801.1 plasmid stability protein Antitoxin
L0Y82_RS03265 (L0Y82_03265) 792071..792490 + 420 WP_006409935.1 type II toxin-antitoxin system VapC family toxin Toxin
L0Y82_RS03270 (L0Y82_03270) 792623..793918 - 1296 WP_035487510.1 aspartate carbamoyltransferase -
L0Y82_RS03275 (L0Y82_03275) 794151..794285 + 135 WP_006409923.1 entericidin A/B family lipoprotein -
L0Y82_RS03280 (L0Y82_03280) 794379..794954 - 576 WP_006409927.1 hypothetical protein -
L0Y82_RS03285 (L0Y82_03285) 795158..796108 - 951 WP_172488721.1 DMT family transporter -
L0Y82_RS03290 (L0Y82_03290) 796621..797415 - 795 WP_006409930.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15146.38 Da        Isoelectric Point: 5.2157

>T231585 WP_006409935.1 NZ_CP090672:792071-792490 [Burkholderia multivorans]
MILVDTNVIFEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLEQSIEHRVVPVFRGRILPFDD
AAGKAYARIRAHARAVGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWAS

Download         Length: 420 bp

>T231585 NZ_CP126931:c4440595-4440245 [Escherichia coli O78:H51]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6298.07 Da        Isoelectric Point: 4.5184

>AT231585 WP_174328801.1 NZ_CP090672:791901-792074 [Burkholderia multivorans]
MHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTRTDPMSFE

Download         Length: 174 bp

>AT231585 NZ_CP126931:c4440840-4440589 [Escherichia coli O78:H51]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References