Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1170797..1171275 Replicon chromosome
Accession NC_011353
Organism Escherichia coli O157:H7 str. EC4115

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A891SFN9
Locus tag ECH74115_RS06120 Protein ID WP_001303876.1
Coordinates 1170797..1171084 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XD67
Locus tag ECH74115_RS06125 Protein ID WP_000536233.1
Coordinates 1171084..1171275 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECH74115_RS06085 1165946..1168417 - 2472 WP_000034474.1 exonuclease -
ECH74115_RS06090 1168511..1168702 - 192 WP_001098307.1 DUF1482 family protein -
ECH74115_RS32490 1168699..1168887 - 189 WP_000413705.1 cell division inhibition protein DicB -
ECH74115_RS06105 1169461..1169646 + 186 WP_001133046.1 hypothetical protein -
ECH74115_RS06110 1169833..1170222 - 390 WP_000394511.1 hypothetical protein -
ECH74115_RS06115 1170364..1170519 - 156 WP_000379575.1 DUF1391 family protein -
ECH74115_RS06120 1170797..1171084 - 288 WP_001303876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECH74115_RS06125 1171084..1171275 - 192 WP_000536233.1 hypothetical protein Antitoxin
ECH74115_RS06130 1171303..1171704 - 402 WP_000986592.1 helix-turn-helix domain-containing protein -
ECH74115_RS06135 1171813..1172085 + 273 WP_000887453.1 helix-turn-helix domain-containing protein -
ECH74115_RS06140 1172069..1172494 + 426 WP_000693855.1 Rha family transcriptional regulator -
ECH74115_RS32505 1172701..1173156 - 456 WP_000273724.1 hypothetical protein -
ECH74115_RS06150 1173235..1174326 + 1092 WP_001205823.1 hypothetical protein -
ECH74115_RS06155 1174333..1175079 + 747 WP_000788745.1 ATP-binding protein -
ECH74115_RS06160 1175101..1175871 + 771 WP_000450992.1 DUF1627 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10978.84 Da        Isoelectric Point: 10.1360

>T23133 WP_001303876.1 NC_011353:c1171084-1170797 [Escherichia coli O157:H7 str. EC4115]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Download         Length: 288 bp

>T23133 NC_011353:c1171084-1170797 [Escherichia coli O157:H7 str. EC4115]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7025.80 Da        Isoelectric Point: 4.0270

>AT23133 WP_000536233.1 NC_011353:c1171275-1171084 [Escherichia coli O157:H7 str. EC4115]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Download         Length: 192 bp

>AT23133 NC_011353:c1171275-1171084 [Escherichia coli O157:H7 str. EC4115]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References