Detailed information of TA system TA230985

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 458121..458827
• Replicon: chromosome
• Accession: NZ_CP090514
• Organism: Xylella fastidiosa subsp. fastidiosa strain Riv13

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: Q87EE2
• Locus tag: LZ753_RS01885
• Protein ID: WP_004090696.1
• Coordinates: 458121..458423 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q87EE1
• Locus tag: LZ753_RS01890
• Protein ID: WP_004090697.1
• Coordinates: 458426..458827 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ753_RS01850 (LZ753_01850)	453889..454578	-	690	WP_012382453.1	contractile injection system protein, VgrG/Pvc8 family	-
LZ753_RS01855 (LZ753_01855)	454508..455479	-	972	WP_011097609.1	hypothetical protein	-
LZ753_RS01860 (LZ753_01860)	455487..456044	-	558	WP_011097610.1	phage tail protein I	-
LZ753_RS01865 (LZ753_01865)	456037..456930	-	894	WP_011097611.1	baseplate J/gp47 family protein	-
LZ753_RS01870 (LZ753_01870)	456930..457292	-	363	WP_014607615.1	GPW/gp25 family protein	-
LZ753_RS01875 (LZ753_01875)	457466..457747	+	282	WP_004090695.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LZ753_RS01880 (LZ753_01880)	457758..458033	+	276	WP_004085172.1	HigA family addiction module antitoxin	-
LZ753_RS01885 (LZ753_01885)	458121..458423	+	303	WP_004090696.1	type II toxin-antitoxin system MqsR family toxin	Toxin
LZ753_RS01890 (LZ753_01890)	458426..458827	+	402	WP_004090697.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
LZ753_RS01895 (LZ753_01895)	458896..459483	-	588	WP_011097612.1	phage baseplate assembly protein V	-
LZ753_RS01900 (LZ753_01900)	459480..460022	-	543	WP_011097613.1	hypothetical protein	-
LZ753_RS01905 (LZ753_01905)	459998..460519	-	522	WP_011097614.1	hypothetical protein	-
LZ753_RS01910 (LZ753_01910)	460516..460839	-	324	WP_011097935.1	hypothetical protein	-
LZ753_RS01915 (LZ753_01915)	460839..461099	-	261	WP_011097616.1	hypothetical protein	-
LZ753_RS01920 (LZ753_01920)	461117..462991	-	1875	WP_011097617.1	phage major capsid protein	-
LZ753_RS01925 (LZ753_01925)	462988..463620	-	633	WP_011097618.1	phage portal protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	446064..468897	22833

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-99)

Antitoxin

• Cro/C1-type helix-turn-helix domain (74-127)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10948.71 Da
• Isoelectric Point: 8.0251

>T230985 WP_004090696.1 NZ_CP090514:458121-458423 [Xylella fastidiosa subsp. fastidiosa]
MEKGTSHYKLPVVKALVKAGKVRATATAYQGARELGIKDLTGMCTVVLALTSADFYKSMTTYADHTVFQDVYHAKTASGD
EVYLKLTVIDDVLIVSFKEL

Nucleotide

• Length: 303 bp

>T230985 NZ_CP125762:c2362695-2362603 [Bacillus subtilis]
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14944.02 Da
• Isoelectric Point: 7.1650

>AT230985 WP_004090697.1 NZ_CP090514:458426-458827 [Xylella fastidiosa subsp. fastidiosa]
MRCPCCGAAELIHDTRDMLYTYKSETTSIPTVTGDFCPACGEVVLDREHGDRYSELVGLFQRQVNSAYVDPGYITKVRRK
LDLDQRQAAELFGGGVNAFSRYENGKTKPPLSLVKLFKLLDRHPDLLNEVKSS

Nucleotide

• Length: 402 bp

>AT230985 NZ_CP125762:2362449-2362622 [Bacillus subtilis]
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT

Structures

Toxin

• AlphaFold DB: Q87EE2

Antitoxin

• AlphaFold DB: Q87EE1