Detailed information of TA system TA230952

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 2589842..2590343
• Replicon: chromosome
• Accession: NZ_CP090508
• Organism: Xylella fastidiosa subsp. morus strain Riv11

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: Q87CA4
• Locus tag: LZ758_RS11925
• Protein ID: WP_011097988.1
• Coordinates: 2589842..2590108 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: LZ758_RS11930
• Protein ID: WP_012382644.1
• Coordinates: 2590092..2590343 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ758_RS11895 (LZ758_11895)	2586484..2587245	-	762	WP_004085598.1	Bax inhibitor-1/YccA family protein	-
LZ758_RS11920 (LZ758_11920)	2588437..2589831	+	1395	WP_040123316.1	hypothetical protein	-
LZ758_RS11925 (LZ758_11925)	2589842..2590108	-	267	WP_011097988.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZ758_RS11930 (LZ758_11930)	2590092..2590343	-	252	WP_012382644.1	DUF6290 family protein	Antitoxin
LZ758_RS11935 (LZ758_11935)	2590430..2590843	+	414	WP_234056426.1	hypothetical protein	-
LZ758_RS12285	2591053..2591181	+	129	WP_267959514.1	hypothetical protein	-
LZ758_RS11940 (LZ758_11940)	2591435..2591815	-	381	WP_038228433.1	DUF596 domain-containing protein	-
LZ758_RS11945 (LZ758_11945)	2591947..2592321	-	375	WP_038228431.1	hypothetical protein	-
LZ758_RS11950 (LZ758_11950)	2592318..2593688	-	1371	WP_230577640.1	DUF769 domain-containing protein	-
LZ758_RS12290	2593842..2593970	+	129	WP_267959513.1	hypothetical protein	-
LZ758_RS11955 (LZ758_11955)	2594224..2594601	-	378	WP_038228427.1	DUF596 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Protein of unknown function DUF6290 (9-79)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10163.79 Da
• Isoelectric Point: 10.6086

>T230952 WP_011097988.1 NZ_CP090508:c2590108-2589842 [Xylella fastidiosa subsp. morus]
MAWTIDYTDTAKQQLRKLDKHMARRIVDFMDERIAGLENPRSSGKALTGPLGGFWRYRVGDFRVVCAIQDSVLRVLVVRV
GHRGEIYR

Nucleotide

• Length: 267 bp

>T230952 NZ_CP125731:c4322461-4322288 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9460.57 Da
• Isoelectric Point: 5.1032

>AT230952 WP_012382644.1 NZ_CP090508:c2590343-2590092 [Xylella fastidiosa subsp. morus]
MHLSGGFDMATSIRLSPEMEQRLNSLASHTGRTKAYYLREIIEHGIEEMEDYYLAADVLERVRHGQEQVHSAADVRKTLG
LDD

Nucleotide

• Length: 252 bp

>AT230952 NZ_CP125731:c4322785-4322489 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A060HDH1