Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3813129..3813785 Replicon chromosome
Accession NZ_CP090244
Organism Serratia marcescens strain SMNSF-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LXH15_RS18325 Protein ID WP_016926704.1
Coordinates 3813129..3813518 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag LXH15_RS18330 Protein ID WP_004941563.1
Coordinates 3813522..3813785 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH15_RS18310 (LXH15_18310) 3809597..3811027 + 1431 WP_016926706.1 multidrug transporter subunit MdtD -
LXH15_RS18315 (LXH15_18315) 3811024..3812406 + 1383 WP_016926705.1 two-component system sensor histidine kinase BaeS -
LXH15_RS18320 (LXH15_18320) 3812406..3813122 + 717 WP_004941568.1 two-component system response regulator BaeR -
LXH15_RS18325 (LXH15_18325) 3813129..3813518 - 390 WP_016926704.1 type II toxin-antitoxin system VapC family toxin Toxin
LXH15_RS18330 (LXH15_18330) 3813522..3813785 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LXH15_RS18335 (LXH15_18335) 3814124..3814462 + 339 WP_016926703.1 YegP family protein -
LXH15_RS18340 (LXH15_18340) 3814641..3815993 + 1353 WP_234213058.1 tRNA 5-hydroxyuridine modification protein YegQ -
LXH15_RS18345 (LXH15_18345) 3816461..3817366 + 906 WP_234213059.1 lipid kinase YegS -
LXH15_RS18350 (LXH15_18350) 3817535..3818749 + 1215 WP_016926700.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14342.61 Da        Isoelectric Point: 7.8794

>T230354 WP_016926704.1 NZ_CP090244:c3813518-3813129 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RATMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T230354 NZ_CP124882:c2692279-2692178 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT230354 WP_004941563.1 NZ_CP090244:c3813785-3813522 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT230354 NZ_CP124882:2692054-2692233 [Enterococcus faecalis]
TGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACACCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGT
TTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACC
GAAAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References