Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3727534..3728095 Replicon chromosome
Accession NZ_CP090244
Organism Serratia marcescens strain SMNSF-1

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LXH15_RS17920 Protein ID WP_234213046.1
Coordinates 3727534..3727746 (-) Length 71 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag LXH15_RS17925 Protein ID WP_004936539.1
Coordinates 3727886..3728095 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH15_RS17900 (LXH15_17900) 3723270..3724067 - 798 WP_079450340.1 TonB family protein -
LXH15_RS17905 (LXH15_17905) 3724170..3725009 - 840 WP_016926769.1 ChaN family lipoprotein -
LXH15_RS17910 (LXH15_17910) 3725187..3726596 + 1410 WP_033639696.1 S-methylmethionine permease -
LXH15_RS17915 (LXH15_17915) 3726586..3727524 + 939 WP_079450341.1 homocysteine S-methyltransferase -
LXH15_RS17920 (LXH15_17920) 3727534..3727746 - 213 WP_234213046.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LXH15_RS17925 (LXH15_17925) 3727886..3728095 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LXH15_RS17930 (LXH15_17930) 3728205..3730484 - 2280 WP_016926766.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
LXH15_RS17935 (LXH15_17935) 3730699..3730872 - 174 WP_170913148.1 hypothetical protein -
LXH15_RS17940 (LXH15_17940) 3730853..3731236 - 384 WP_049299550.1 DUF2570 family protein -
LXH15_RS17945 (LXH15_17945) 3731233..3731634 - 402 WP_234213047.1 M15 family metallopeptidase -
LXH15_RS17950 (LXH15_17950) 3731624..3731950 - 327 WP_234213048.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(2-31)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7718.88 Da        Isoelectric Point: 5.5354

>T230353 WP_234213046.1 NZ_CP090244:c3727746-3727534 [Serratia marcescens]
MAALYLIAISHGHIFLDGNKRTAFQSMALFLGINGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE

Download         Length: 213 bp

>T230353 NZ_CP124882:c2691846-2691745 [Enterococcus faecalis]
TTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGCACTACTGATTTTCGGTATCCTTGAAGC
AACGAAAAACGATAAAAAATAA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT230353 WP_004936539.1 NZ_CP090244:c3728095-3727886 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT230353 NZ_CP124882:2691623-2691800 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References