Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1731332..1731857 Replicon chromosome
Accession NZ_CP090244
Organism Serratia marcescens strain SMNSF-1

Toxin (Protein)


Gene name relE Uniprot ID A0A8G2G914
Locus tag LXH15_RS08270 Protein ID WP_016928357.1
Coordinates 1731332..1731616 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A542C2P2
Locus tag LXH15_RS08275 Protein ID WP_016928356.1
Coordinates 1731606..1731857 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH15_RS08245 (LXH15_08245) 1726592..1727725 + 1134 WP_116403735.1 putrescine ABC transporter ATP-binding subunit PotG -
LXH15_RS08250 (LXH15_08250) 1727750..1728712 + 963 WP_016928361.1 putrescine ABC transporter permease PotH -
LXH15_RS08255 (LXH15_08255) 1728709..1729554 + 846 WP_016928360.1 putrescine ABC transporter permease PotI -
LXH15_RS08260 (LXH15_08260) 1729659..1730138 + 480 WP_028127974.1 YbjO family protein -
LXH15_RS08265 (LXH15_08265) 1730208..1731335 + 1128 WP_028127975.1 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC -
LXH15_RS08270 (LXH15_08270) 1731332..1731616 - 285 WP_016928357.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXH15_RS08275 (LXH15_08275) 1731606..1731857 - 252 WP_016928356.1 prevent-host-death protein Antitoxin
LXH15_RS08280 (LXH15_08280) 1731959..1732693 - 735 WP_016928355.1 arginine ABC transporter substrate-binding protein -
LXH15_RS08285 (LXH15_08285) 1732893..1733561 - 669 WP_033637817.1 arginine ABC transporter permease ArtM -
LXH15_RS08290 (LXH15_08290) 1733561..1734277 - 717 WP_028127976.1 arginine ABC transporter permease ArtQ -
LXH15_RS08295 (LXH15_08295) 1734287..1735018 - 732 WP_004928409.1 arginine ABC transporter substrate-binding protein -
LXH15_RS08300 (LXH15_08300) 1735051..1735779 - 729 WP_110147567.1 arginine ABC transporter ATP-binding protein ArtP -
LXH15_RS08305 (LXH15_08305) 1736043..1736585 - 543 WP_097102449.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10775.89 Da        Isoelectric Point: 10.6941

>T230344 WP_016928357.1 NZ_CP090244:c1731616-1731332 [Serratia marcescens]
MTYKLEFEEHALKEFKKLSPAIREQFKKKLASVLVNPHVPANKLAGLPDCYKIKLRASGFRLVYRIMETEIVVLVLSVGK
RERSAAYTAAKKRL

Download         Length: 285 bp

>T230344 NZ_CP124873:c4801838-4800921 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9108.39 Da        Isoelectric Point: 4.5203

>AT230344 WP_016928356.1 NZ_CP090244:c1731857-1731606 [Serratia marcescens]
MTVQPILADSAVSISDFKKSPNAALKEAQGQPVAVLTNGKISGYYVSPETWEAIAEYLEDLELAEIVRSRMNGKRIKVNL
DDL

Download         Length: 252 bp

>AT230344 NZ_CP124873:c4802602-4801844 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATATGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A542C2P2

References