Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1601592..1602140 Replicon chromosome
Accession NZ_CP090244
Organism Serratia marcescens strain SMNSF-1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LXH15_RS07695 Protein ID WP_028127948.1
Coordinates 1601838..1602140 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag LXH15_RS07690 Protein ID WP_025302143.1
Coordinates 1601592..1601828 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXH15_RS07675 (LXH15_07675) 1598078..1599613 + 1536 WP_234214021.1 glutathione ABC transporter substrate-binding protein GsiB -
LXH15_RS07680 (LXH15_07680) 1599666..1600586 + 921 WP_016928458.1 glutathione ABC transporter permease GsiC -
LXH15_RS07685 (LXH15_07685) 1600596..1601504 + 909 WP_016928457.1 glutathione ABC transporter permease GsiD -
LXH15_RS07690 (LXH15_07690) 1601592..1601828 + 237 WP_025302143.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LXH15_RS07695 (LXH15_07695) 1601838..1602140 + 303 WP_028127948.1 CcdB family protein Toxin
LXH15_RS07700 (LXH15_07700) 1602176..1603018 - 843 WP_015377214.1 S-formylglutathione hydrolase -
LXH15_RS07705 (LXH15_07705) 1603033..1604157 - 1125 WP_016928454.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
LXH15_RS07710 (LXH15_07710) 1604188..1605108 - 921 WP_116403718.1 LysR family transcriptional regulator -
LXH15_RS07715 (LXH15_07715) 1605214..1606371 + 1158 WP_079450985.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-99)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11210.98 Da        Isoelectric Point: 5.0196

>T230343 WP_028127948.1 NZ_CP090244:1601838-1602140 [Serratia marcescens]
ITVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKAVG
NVNEHRNQIKAAIDFLIDGF

Download         Length: 303 bp

>T230343 NZ_CP124873:c4645728-4645444 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8967.04 Da        Isoelectric Point: 5.0807

>AT230343 WP_025302143.1 NZ_CP090244:1601592-1601828 [Serratia marcescens]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT230343 NZ_CP124873:c4645960-4645718 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References