Detailed information of TA system TA230319

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4682012..4683693
• Replicon: chromosome
• Accession: NZ_CP090222
• Organism: Klebsiella pneumoniae strain BY11

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: LVJ01_RS22890
• Protein ID: WP_004178299.1
• Coordinates: 4682012..4682929 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: LVJ01_RS22895
• Protein ID: WP_004177809.1
• Coordinates: 4682935..4683693 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LVJ01_RS22870 (4677318)	4677318..4678838	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
LVJ01_RS22875 (4678835)	4678835..4679833	+	999	WP_002885172.1	ribose ABC transporter permease	-
LVJ01_RS22880 (4679864)	4679864..4680805	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
LVJ01_RS22885 (4680880)	4680880..4681887	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
LVJ01_RS22890 (4682012)	4682012..4682929	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LVJ01_RS22895 (4682935)	4682935..4683693	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LVJ01_RS22900 (4683779)	4683779..4684507	-	729	WP_004178298.1	response regulator transcription factor	-
LVJ01_RS22905 (4684780)	4684780..4686927	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
LVJ01_RS22910 (4687157)	4687157..4687843	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T230319 WP_004178299.1 NZ_CP090222:c4682929-4682012 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T230319 NZ_CP124842:c96244-94937 [Aeromonas salmonicida]
ATGCAGACGCTAAACGTGGCGATGAATGGTGAGATCGTAGGCACACTGTACCGAGATAACAGAGGGGCCATGTCATTTCA
GTATGCCCCAGAGTGGATCTCGGAGCCAGGTTCACGCGCTATTTCCATGTCACTGCCTTTGAGTCATAGCAGGATCACAG
GAAGTGAAGTCTTCAATTTCTTTAGCAACCTCCTACCTGACTCAGAGGCAATTATTGCCAGGATGCAGGCCCGGTTCAGC
GTTGAGACAACACATCCATTTGATTTGCTGGCGAGTGTTGGCCGGGACTGTGTTGGAGCTATCCAGCTCTATTCCCCCGA
TGCTGACATCCCAACTGTAATGGAGACGCTTGCAGAGCCTCTGGATGACGCGCAGATTGAGCAACTGCTTGAAGGCTATC
AGGAAGCTCCCCTTGGGATGGCGGAGGATGCTGATTTCCGGATCTCGATTGCCGGAGCCCAAGAGAAAACTGCACTGCTT
TGGTACCAAGATTGCTGGCAACGCCCTCTGGGCAGTACGCCAACAAGCCATATTTTTAAGCTACCCATTGGCAAAATTGT
TCAAAATAACATCGACCTCAGCGAGAGTTGCGAGAATGAATGGCTCTGTTTGCGCATTGCAAAGGCCTTCGGATTTGACG
TCGCCAATGCGGATCTAGCCACGTTCGGCAAGCAGAAGGTGCTTGTCGTTCAGCGTTTTGACCGGCGCTGGTCGAAATCC
GGCGAATGGCTTCTGCGATTGCCCCAAGAAGACTTCTGCCAAGCTCTTGGAATCGCCCCTGCGCTCAAATACGAGTCCCA
TGGTGGGCCAGGTATTGCTGATGCAATGAAGTTATTGTTGGGATCCAGACTTGCGGCCAAGGATAGAGAGCAATTTTTCA
AGTCGCAGATCCTATTCTGGATGTTGGCCGCGATCGATGGGCACGGGAAGAACTTCTCCATCTTCATTGAGCCTGCATCG
TCATTTAGGATGACTCCCCTCTACGATGTCATGTCTGCTTTTCCTATCTTCAAAAGCGGGGGAATTGCAGCTCAAAAGGC
AAAGATGGGGATGGCGCTCCAAGGCAAAAACCGCCAATACCATTTTGCGATGATCCAGCCTCGTCATTTTATCAGTACCG
CCGCCCATGTCGGGTTCCCACAAGATACCGCAGCTCAACTTATGCTCGAAATGGCTACCAAGACAGAGGCGGTGGTCGCC
ACAGTAGCCGCCGAGCTGCCAGCCGGTTTCCCAGAACACATTAGCAATACCATCTTCGATGGGCTAGCCAGCCAGGCGGC
TAAGATCTTGAAGGGGGTAGCCAAATGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT230319 WP_004177809.1 NZ_CP090222:c4683693-4682935 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT230319 NZ_CP124842:c96505-96254 [Aeromonas salmonicida]
ATGAAAGTAACATCTCCAGCCTTACTTGCGGCTGCGGTTCGTGACCAACGCAAGATCAGCAAGCTAACGCAGGCAGAGGC
GGCGAAACAGGTCGGAATCAAGCAGACAACCGTCTCTGATTTTGAACTACGGCCAGAATCTACCAAGCTGGAGACGCTAT
TCAAGCTCCTTTCTGCTCTGGATCTGGAGCTTCATGTCGTGAAGCGGGGCTCAACATTGGACGATAATAAAGTCTGGGAT
AGGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A6TH05