Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 577962..578509 Replicon chromosome
Accession NZ_CP090179
Organism Vibrio harveyi strain XH2145

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR19
Locus tag LXG94_RS12975 Protein ID WP_025548916.1
Coordinates 578207..578509 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0C1ZM65
Locus tag LXG94_RS12970 Protein ID WP_020196830.1
Coordinates 577962..578219 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXG94_RS12900 (LXG94_12900) 573075..573326 + 252 WP_127891278.1 hypothetical protein -
LXG94_RS12905 (LXG94_12905) 573348..573440 + 93 WP_079400415.1 DUF3265 domain-containing protein -
LXG94_RS12910 (LXG94_12910) 573859..573987 + 129 WP_077200607.1 DUF3265 domain-containing protein -
LXG94_RS12915 (LXG94_12915) 574015..574890 + 876 WP_079403009.1 hypothetical protein -
LXG94_RS12920 (LXG94_12920) 574908..574997 + 90 Protein_618 DUF3265 domain-containing protein -
LXG94_RS12925 (LXG94_12925) 575034..575309 + 276 WP_233921906.1 hypothetical protein -
LXG94_RS12930 (LXG94_12930) 575730..575822 + 93 WP_079856556.1 DUF3265 domain-containing protein -
LXG94_RS12935 (LXG94_12935) 575851..576477 + 627 WP_127891277.1 hypothetical protein -
LXG94_RS12940 (LXG94_12940) 576474..576584 + 111 WP_080640418.1 DUF3265 domain-containing protein -
LXG94_RS12945 (LXG94_12945) 576624..577013 + 390 WP_038899565.1 DUF4345 domain-containing protein -
LXG94_RS12950 (LXG94_12950) 577031..577120 + 90 WP_072609598.1 DUF3265 domain-containing protein -
LXG94_RS12955 (LXG94_12955) 577150..577767 + 618 WP_053051989.1 LysE family translocator -
LXG94_RS12960 (LXG94_12960) 577764..577826 + 63 Protein_626 DUF3265 domain-containing protein -
LXG94_RS12970 (LXG94_12970) 577962..578219 + 258 WP_020196830.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LXG94_RS12975 (LXG94_12975) 578207..578509 + 303 WP_025548916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXG94_RS12980 (LXG94_12980) 578548..578637 + 90 WP_079755141.1 DUF3265 domain-containing protein -
LXG94_RS12985 (LXG94_12985) 578710..579072 + 363 WP_038899247.1 hypothetical protein -
LXG94_RS12990 (LXG94_12990) 579096..579184 + 89 Protein_631 DUF3265 domain-containing protein -
LXG94_RS12995 (LXG94_12995) 579222..580163 + 942 WP_038899246.1 DUF2971 domain-containing protein -
LXG94_RS13000 (LXG94_13000) 580178..580270 + 93 WP_193788543.1 DUF3265 domain-containing protein -
LXG94_RS13005 (LXG94_13005) 580705..580794 + 90 WP_076665338.1 DUF3265 domain-containing protein -
LXG94_RS13010 (LXG94_13010) 580833..581384 + 552 WP_038899244.1 GrpB family protein -
LXG94_RS13015 (LXG94_13015) 581413..581505 + 93 WP_005433818.1 DUF3265 domain-containing protein -
LXG94_RS13020 (LXG94_13020) 581550..582047 + 498 WP_038899243.1 hypothetical protein -
LXG94_RS13025 (LXG94_13025) 582079..582171 + 93 WP_006074995.1 DUF3265 domain-containing protein -
LXG94_RS13030 (LXG94_13030) 583200..583329 + 130 Protein_639 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 509766..632527 122761
- inside Integron - - 508515..626933 118418


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11669.57 Da        Isoelectric Point: 5.1765

>T230160 WP_025548916.1 NZ_CP090179:578207-578509 [Vibrio harveyi]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T230160 NZ_CP124740:1374651-1374869 [Escherichia coli O157:H7 str. EDL933]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9605.15 Da        Isoelectric Point: 8.5338

>AT230160 WP_020196830.1 NZ_CP090179:577962-578219 [Vibrio harveyi]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDKAKDKM
SKWLK

Download         Length: 258 bp

>AT230160 NZ_CP124740:1374251-1374625 [Escherichia coli O157:H7 str. EDL933]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACTCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR19

Antitoxin

Source ID Structure
AlphaFold DB A0A0C1ZM65

References