Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 510446..510993 Replicon chromosome
Accession NZ_CP090179
Organism Vibrio harveyi strain XH2145

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR19
Locus tag LXG94_RS12170 Protein ID WP_025548916.1
Coordinates 510691..510993 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0C1ZM65
Locus tag LXG94_RS12165 Protein ID WP_020196830.1
Coordinates 510446..510703 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LXG94_RS12135 (LXG94_12135) 506795..507379 + 585 WP_005445212.1 ribosomal protein S5-alanine N-acetyltransferase -
LXG94_RS12140 (LXG94_12140) 507380..507967 + 588 WP_038899423.1 HD domain-containing protein -
LXG94_RS12145 (LXG94_12145) 507981..508454 + 474 WP_038899424.1 DUF2947 domain-containing protein -
LXG94_RS12150 (LXG94_12150) 508515..509477 - 963 WP_038899425.1 integron integrase -
LXG94_RS12155 (LXG94_12155) 509766..510257 + 492 WP_038899426.1 hypothetical protein -
LXG94_RS12160 (LXG94_12160) 510272..510364 + 93 WP_005445734.1 DUF3265 domain-containing protein -
LXG94_RS12165 (LXG94_12165) 510446..510703 + 258 WP_020196830.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LXG94_RS12170 (LXG94_12170) 510691..510993 + 303 WP_025548916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LXG94_RS12175 (LXG94_12175) 511032..511121 + 90 WP_072016691.1 DUF3265 domain-containing protein -
LXG94_RS12180 (LXG94_12180) 511148..511450 + 303 WP_038899769.1 hypothetical protein -
LXG94_RS12185 (LXG94_12185) 511652..512461 + 810 WP_038899770.1 Bro-N domain-containing protein -
LXG94_RS12190 (LXG94_12190) 512476..512568 + 93 WP_079750017.1 DUF3265 domain-containing protein -
LXG94_RS12195 (LXG94_12195) 512642..513466 + 825 WP_038899771.1 nucleotide-binding protein -
LXG94_RS12200 (LXG94_12200) 513502..513594 + 93 WP_169786531.1 DUF3265 domain-containing protein -
LXG94_RS12205 (LXG94_12205) 513660..513890 - 231 WP_015296894.1 DUF2188 domain-containing protein -
LXG94_RS12210 (LXG94_12210) 514021..514110 + 90 WP_227740494.1 DUF3265 domain-containing protein -
LXG94_RS12215 (LXG94_12215) 514137..514856 + 720 WP_050567854.1 HNH endonuclease -
LXG94_RS12220 (LXG94_12220) 515382..515510 + 129 WP_099098883.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 509766..632527 122761
- inside Integron - - 508515..626933 118418


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11669.57 Da        Isoelectric Point: 5.1765

>T230157 WP_025548916.1 NZ_CP090179:510691-510993 [Vibrio harveyi]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T230157 NZ_CP124740:518591-518698 [Escherichia coli O157:H7 str. EDL933]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9605.15 Da        Isoelectric Point: 8.5338

>AT230157 WP_020196830.1 NZ_CP090179:510446-510703 [Vibrio harveyi]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDKAKDKM
SKWLK

Download         Length: 258 bp

>AT230157 NZ_CP124740:c518543-518484 [Escherichia coli O157:H7 str. EDL933]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR19

Antitoxin

Source ID Structure
AlphaFold DB A0A0C1ZM65

References