Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2622725..2624313 Replicon chromosome
Accession NZ_CP089882
Organism Klebsiella pneumoniae strain KP059

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag LVQ69_RS12930 Protein ID WP_004190166.1
Coordinates 2622725..2624047 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LVQ69_RS12935 Protein ID WP_002904790.1
Coordinates 2624047..2624313 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ69_RS12915 (LVQ69_12895) 2617781..2620282 + 2502 WP_277710552.1 fimbria/pilus outer membrane usher protein -
LVQ69_RS12920 (LVQ69_12900) 2620270..2621274 + 1005 WP_004190163.1 fimbrial protein -
LVQ69_RS12925 (LVQ69_12905) 2621416..2622708 + 1293 WP_277710553.1 glycoside hydrolase family 10 protein -
LVQ69_RS12930 (LVQ69_12910) 2622725..2624047 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
LVQ69_RS12935 (LVQ69_12915) 2624047..2624313 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LVQ69_RS12940 (LVQ69_12920) 2624578..2624904 - 327 WP_004143476.1 hydroxyisourate hydrolase -
LVQ69_RS12945 (LVQ69_12925) 2624901..2625401 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LVQ69_RS12950 (LVQ69_12930) 2625379..2626758 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
LVQ69_RS12955 (LVQ69_12935) 2627104..2628258 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LVQ69_RS12960 (LVQ69_12940) 2628239..2629162 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T229584 WP_004190166.1 NZ_CP089882:c2624047-2622725 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T229584 NZ_CP124495:2216842-2216944 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT229584 WP_002904790.1 NZ_CP089882:c2624313-2624047 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT229584 NZ_CP124495:c2216982-2216714 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References