Detailed information of TA system TA022958

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 1822470..1823109
• Replicon: chromosome
• Accession: NC_011001
• Organism: Burkholderia cenocepacia J2315

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: QU43_RS62570
• Protein ID: WP_006481544.1
• Coordinates: 1822470..1822886 (-)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A364H554
• Locus tag: QU43_RS62575
• Protein ID: WP_006481537.1
• Coordinates: 1822873..1823109 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QU43_RS62545	1817577..1818677	-	1101	WP_006481534.1	nitronate monooxygenase	-
QU43_RS62550	1818674..1819594	-	921	WP_006481536.1	enoyl-CoA hydratase	-
QU43_RS62555	1819603..1820400	-	798	WP_006481539.1	hypothetical protein	-
QU43_RS62560	1820411..1821304	-	894	WP_006481548.1	CoA transferase subunit A	-
QU43_RS62565	1821314..1822210	-	897	WP_006481531.1	VOC family protein	-
QU43_RS62570	1822470..1822886	-	417	WP_006481544.1	type II toxin-antitoxin system VapC family toxin	Toxin
QU43_RS62575	1822873..1823109	-	237	WP_006481537.1	DNA-binding protein	Antitoxin
QU43_RS62580	1823602..1824828	+	1227	WP_006481535.1	acyltransferase	-
QU43_RS62585	1824839..1825516	-	678	WP_077176171.1	hypothetical protein	-
QU43_RS62590	1826165..1826938	-	774	WP_006481545.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15402.64 Da
• Isoelectric Point: 6.8818

>T22958 WP_006481544.1 NC_011001:c1822886-1822470 [Burkholderia cenocepacia J2315]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLTMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE

Nucleotide

• Length: 417 bp

>T22958 NC_011001:c1822886-1822470 [Burkholderia cenocepacia J2315]
GTGTTTTTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGAGGGCGTTCTTCAG
GCAGGCCGAAGCGGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGCTGCGGCGCGGTGTCGACCTGATCC
GTCATCGCGGCGATCACAGCCAGGCGTCGGCGCTCGAGGCCTGGCTGACGATGATCCTGTCCGGCTATGCGCCGAACATC
CTGCCGGTCGATGTCGAAACCGGCCAGATGTGGGGGCATTTGCGCGTGCCCGATCCGACGCACGAACTCGACAAGCTGAT
CGCGGCCACCGCATTGATCAACGATTTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACCGGCGTCCGGTTGC
TGAATCCGTTCGAGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8710.78 Da
• Isoelectric Point: 5.0916

>AT22958 WP_006481537.1 NC_011001:c1823109-1822873 [Burkholderia cenocepacia J2315]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT22958 NC_011001:c1823109-1822873 [Burkholderia cenocepacia J2315]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTCTCGTTCAAAGCCTGCGCGAGCAGGCTGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAAGCGCTCGGCCGGCCGAAGCGGCGCACATTCGCGCAAGTGCTGATGA
GCATGCCGGAGGTGGGCGAAGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A364H554