Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 812167..812824 Replicon chromosome
Accession NZ_CP089880
Organism Klebsiella pneumoniae strain KP309

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LVQ72_RS04055 Protein ID WP_002916310.1
Coordinates 812414..812824 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LVQ72_RS04050 Protein ID WP_002916312.1
Coordinates 812167..812433 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LVQ72_RS04025 (LVQ72_04025) 807323..808756 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
LVQ72_RS04030 (LVQ72_04030) 808875..809603 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LVQ72_RS04035 (LVQ72_04035) 809653..809964 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LVQ72_RS04040 (LVQ72_04040) 810128..810787 + 660 WP_002916317.1 hemolysin III family protein -
LVQ72_RS04045 (LVQ72_04045) 810938..811921 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
LVQ72_RS04050 (LVQ72_04050) 812167..812433 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LVQ72_RS04055 (LVQ72_04055) 812414..812824 + 411 WP_002916310.1 protein YgfX Toxin
LVQ72_RS04060 (LVQ72_04060) 812831..813352 - 522 WP_002916308.1 flavodoxin FldB -
LVQ72_RS04065 (LVQ72_04065) 813453..814349 + 897 WP_004185550.1 site-specific tyrosine recombinase XerD -
LVQ72_RS04070 (LVQ72_04070) 814372..815085 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LVQ72_RS04075 (LVQ72_04075) 815091..816824 + 1734 WP_004185546.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T229554 WP_002916310.1 NZ_CP089880:812414-812824 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T229554 NZ_CP124492:188541-188648 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGTTCCGGTCATTACTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT229554 WP_002916312.1 NZ_CP089880:812167-812433 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT229554 NZ_CP124492:c188484-188427 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References