Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4608210..4608964 Replicon chromosome
Accession NZ_CP089799
Organism Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00785

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag LUY21_RS22245 Protein ID WP_000558166.1
Coordinates 4608210..4608521 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LUY21_RS22250 Protein ID WP_001259011.1
Coordinates 4608518..4608964 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LUY21_RS22215 (4603868) 4603868..4604770 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
LUY21_RS22220 (4604767) 4604767..4605402 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
LUY21_RS22225 (4605399) 4605399..4606328 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
LUY21_RS22230 (4606375) 4606375..4606665 - 291 WP_000362052.1 DNA-binding transcriptional regulator -
LUY21_RS22235 (4606666) 4606666..4606977 - 312 WP_023138876.1 hypothetical protein -
LUY21_RS22240 (4607195) 4607195..4608124 + 930 WP_001127698.1 alpha/beta hydrolase -
LUY21_RS22245 (4608210) 4608210..4608521 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
LUY21_RS22250 (4608518) 4608518..4608964 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
LUY21_RS22255 (4608979) 4608979..4609920 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
LUY21_RS22260 (4609965) 4609965..4610402 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
LUY21_RS22265 (4610399) 4610399..4611271 - 873 WP_000921423.1 virulence factor BrkB family protein -
LUY21_RS22270 (4611265) 4611265..4611864 - 600 WP_000965695.1 glucose-1-phosphatase -
LUY21_RS22275 (4612055) 4612055..4612858 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
LUY21_RS22280 (4612892) 4612892..4613788 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T229474 WP_000558166.1 NZ_CP089799:4608210-4608521 [Salmonella enterica subsp. enterica serovar Kentucky]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T229474 NZ_CP124481:c2315356-2315249 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT229474 WP_001259011.1 NZ_CP089799:4608518-4608964 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT229474 NZ_CP124481:2315404-2315470 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90

Antitoxin

Source ID Structure

References